"RNF7" Related Products


Recombinant Human RNF7, His-tagged

Cat.No.: RNF7-2286H
Product Overview: Recombinant human RNF7 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Description: RNF7 is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea
Molecular Mass: 15.1 kDa
Protein length: 136aa
Purity: >90% by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration: 1.0 mg/ml
Gene Name: RNF7 ring finger protein 7 [ Homo sapiens ]
Official Symbol: RNF7
Synonyms: RNF7; ring finger protein 7; RING-box protein 2; CKBBP1; ROC2; SAG; sensitive to apoptosis; zinc RING finger protein SAG; regulator of cullins 2; rbx2; CKII beta-binding protein 1; sensitive to apoptosis gene protein; sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2;
Gene ID: 9616
mRNA Refseq: NM_001201370
Protein Refseq: NP_001188299
MIM: 603863
UniProt ID: Q9UBF6
Chromosome Location: 3q22-q24
Pathway: ECS complex, organism-specific biosystem; ECS complex, conserved biosystem; Ubiquitin mediated proteolysis, organism-specific biosystem; Ubiquitin mediated proteolysis, conserved biosystem;
Function: NEDD8 ligase activity; copper ion binding; metal ion binding; protein binding; zinc ion binding;

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