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Recombinant Human ASCC1, His-tagged

Cat.No. : ASCC1-2303H
Product Overview : Recombinant human ASCC1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
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Description : ASCC1 is a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in ASCC1 are associated with Barrett esophagus and esophageal adenocarcinoma.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Molecular Mass : 43.6 kDa
Protein length : 380aa
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSMEVLRPQ LIRIDGRNYR KNPVQEQTYQ HEEDEEDFYQ GSMECADEPC DAYEVEQTPQ GFRSTLRAPS LLYKHIVGKR GDTRKKIEME TKTSISIPKP GQDGEIVITG QHRNGVISAR TRIDVLLDTF RRKQPFTHFL AFFLNEVEVQ EGFLRFQEEV LAKCSMDHGV DSSIFQNPKK LHLTIGMLVL LSEEEIQQTC EMLQQCKEEF INDISGGKPL EVEMAGIEYM NDDPGMVDVL YAKVHMKDGS NRLQELVDRV LERFQASGLI VKEWNSVKLH ATVMNTLFRK DPNAEGRYNL YTAEGKYIFK ERESFDGRNI LKLFENFYFG SLKLNSIHIS QRFTVDSFGN YASCGQIDFS
Purity : >90% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration : 0.5 mg/ml
Gene Name : ASCC1 activating signal cointegrator 1 complex subunit 1 [ Homo sapiens ]
Official Symbol : ASCC1
Synonyms : ASCC1; activating signal cointegrator 1 complex subunit 1; ASC1p50; CGI 18; Em:AC022392.3; ASC-1 complex subunit P50; trip4 complex subunit p50; p50; CGI-18;
Gene ID : 51008
mRNA Refseq : NM_001198798
Protein Refseq : NP_001185727
MIM : 614215
UniProt ID : Q8N9N2
Chromosome Location : 10pter-q25.3
Function : RNA binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is ASCC1 localization regulated within the cell? 01/31/2020

ASCC1 is primarily localized in the nucleus of cells, where it functions in gene expression regulation. It is believed to shuttle between the nucleus and cytoplasm upon specific cellular signaling events.

Does ASCC1 have any post-translational modifications? 12/12/2019

The post-translational modifications of ASCC1 have not been extensively studied. However, it is possible that ASCC1 undergoes modifications such as phosphorylation or acetylation, which can regulate its function.

Does ASCC1 have any role in DNA repair processes? 11/07/2019

Yes, ASCC1 is involved in DNA repair processes as part of the ASC-1 complex. It participates in the repair of DNA double-strand breaks, contributing to genome stability.

In which tissues or cell types is ASCC1 expressed? 12/30/2018

ASCC1 is expressed in a wide range of tissues and cell types, including but not limited to the brain, liver, heart, and skeletal muscle.

Is there any association between ASCC1 and human diseases? 07/21/2017

Currently, there are no known human diseases directly associated with ASCC1. However, dysregulation of transcriptional coactivation complexes, in which ASCC1 is involved, can contribute to various diseases.

Can ASCC1 be targeted for therapeutic interventions or drug discovery? 09/09/2016

Given the limited understanding of ASCC1's specific role in diseases, it is currently uncertain if it can be directly targeted for therapeutic interventions or drug discovery.

What are the known interacting partners of ASCC1? 06/11/2016

ASCC1 interacts with various proteins and transcription factors, such as ATF2, TAF12, and TRIM28, to form the ASC-1 complex and regulate gene expression.

Customer Reviews (3)

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Reviews
11/25/2022

    the use of ASCC1 protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.

    05/24/2018

      The manufacturer's support and expertise further enhance the utility of ASCC1 in my experimental work, ensuring reliable and high-quality results.

      11/13/2017

        This collaborative partnership greatly contributes to the success of my research projects and facilitates meaningful contributions to the scientific community.

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