"XRN1" Related Products


Recombinant Human XRN1, His-tagged

Cat.No.: XRN1-102H
Product Overview: The protein was expressed as 6*his-tagged fusion protein by E.Coli and puri?ed by Ni-sepharose.
Description: SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.
Source: E.Coli
Species: Human
Tag: His
AA Sequence: 222-576aa
Storage: The protein is stored in PBS bu?er at -20 oC. Repeated freezethaw cycles should be avoided.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name: XRN1 5'-3' exoribonuclease 1 [ Homo sapiens (human) ]
Official Symbol: XRN1
Synonyms: XRN1; SEP1; 5'-3' exoribonuclease 1; strand-exchange protein 1 homolog
Gene ID: 54464
mRNA Refseq: NM_019001
Protein Refseq: NP_061874
MIM: 607994
UniProt ID: Q8IZH2
Chromosome Location: 3q23
Pathway: Deadenylation-dependent mRNA decay; Destabilization of mRNA by Butyrate Response Factor 1 (BRF1); Destabilization of mRNA by Tristetraprolin (TTP)
Function: 5'-3' exonuclease activity; DNA binding; RNA binding; protein binding

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