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Recombinant Human XRN1, His-tagged

Cat.No. : XRN1-102H
Product Overview : The protein was expressed as 6*his-tagged fusion protein by E.Coli and puri?ed by Ni-sepharose.
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Description : SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.
Source : E.Coli
Species : Human
Tag : His
AA Sequence : 222-576aa
Storage : The protein is stored in PBS bu?er at -20 oC. Repeated freezethaw cycles should be avoided.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : XRN1 5'-3' exoribonuclease 1 [ Homo sapiens (human) ]
Official Symbol : XRN1
Synonyms : XRN1; SEP1; 5'-3' exoribonuclease 1; strand-exchange protein 1 homolog
Gene ID : 54464
mRNA Refseq : NM_019001
Protein Refseq : NP_061874
MIM : 607994
UniProt ID : Q8IZH2
Chromosome Location : 3q23
Pathway : Deadenylation-dependent mRNA decay; Destabilization of mRNA by Butyrate Response Factor 1 (BRF1); Destabilization of mRNA by Tristetraprolin (TTP)
Function : 5'-3' exonuclease activity; DNA binding; RNA binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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