Recombinant Human XRN1, His-tagged

• Cat.No.: XRN1-102H
• Product Overview: The protein was expressed as 6*his-tagged fusion protein by E.Coli and puri?ed by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.
• AA Sequence: 222-576aa
• Storage: The protein is stored in PBS bu?er at -20 oC. Repeated freezethaw cycles should be avoided.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: XRN1 5'-3' exoribonuclease 1 [ Homo sapiens (human) ]
• Official Symbol: XRN1
• Synonyms: XRN1; SEP1; 5'-3' exoribonuclease 1; strand-exchange protein 1 homolog
• Gene ID: 54464
• mRNA Refseq: NM_019001
• Protein Refseq: NP_061874
• MIM: 607994
• UniProt ID: Q8IZH2
• Chromosome Location: 3q23
• Pathway: Deadenylation-dependent mRNA decay; Destabilization of mRNA by Butyrate Response Factor 1 (BRF1); Destabilization of mRNA by Tristetraprolin (TTP)
• Function: 5'-3' exonuclease activity; DNA binding; RNA binding; protein binding