Active Human CCL3

• Cat.No.: CCL3-109H
• Product Overview: It is a synthetic Protein

Specification

• Description: MIP-1 (Macrophage Inflammatory Protein 1 or CCL3) is a monocyte chemoattractant which has chemoattractant and adhesive effects on lymphocytes, preferentially attracting CD8+ cells. MIP-1 has also been shown to attract B cells and also eosinophils. It has also been identified as a stem cell inhibitory factor which can inhibit the proliferation of hematopoietic stem cells in vitro and in vivo. Receptors for MIP-1 are CCR1 and CCR5.
• Species: Human
• Form: Lyophilized
• Bio-activity: Activity measured by the protein's ability to chemoattract cultured human monocytes. ED50 for this effect is 2-12 ng/ml.
• Applications: Activity Assay
• Storage: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
• Reconstitution: Recommended reconstitution in sterile phosphate buffered saline which contains at least 0.1% human or bovine serum albumin to prepare a stocksolution of no less than 20 μg/ml and vortex thoroughly.

Gene Information

• Gene Name: CCL3 chemokine (C-C motif) ligand 3 [ Homo sapiens ]
• Official Symbol: CCL3
• Synonyms: CCL3; chemokine (C-C motif) ligand 3; SCYA3, small inducible cytokine A3 (homologous to mouse Mip 1a); C-C motif chemokine 3; G0S19 1; LD78ALPHA; MIP 1 alpha; SIS-beta; PAT 464.1; G0/G1 switch regulatory protein 19-1; macrophage inflammatory protein 1-alpha; tonsillar lymphocyte LD78 alpha protein; small inducible cytokine A3 (homologous to mouse Mip-1a); MIP1A; SCYA3; G0S19-1; MIP-1-alpha
• Gene ID: 6348
• mRNA Refseq: NM_002983
• Protein Refseq: NP_002974
• MIM: 182283
• UniProt ID: P10147
• Chromosome Location: 17q12
• Pathway: Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem
• Function: CCR1 chemokine receptor binding; CCR5 chemokine receptor binding; calcium-dependent protein kinase C activity; chemoattractant activity; chemokine activity; kinase activity; phospholipase activator activity; protein binding; protein kinase activity