Recombinant Human RAP1A, GST-tagged
Cat.No. : | RAP1A-118H |
Product Overview : | Recombinant Human RAP1A fused with?a GST tag, was expressed in E. Coli. |
- Specification
- Gene Information
- Related Products
Description : | Rap1A is a 21 kDa small GTP-binding protein that antagonizes the Ras transforming activity through tight binding to Ras-GAP. It interferes with Ras-dependent Raf1 activation by inhibiting binding of Ras to the cysteine-rich region of Raf1. This protein is localized in the endoplasmic reticulum, late endosomes, and lysosomes, indicating its potential role in the regulation of intracellular protein degradation. Rap1a contains a C-terminal CLLL motif for post-translational geranylgeranylation and a single site for phosphorylation by protein kinase A. Ras proteins provide a crucial link in the intracellular signalling cascades. Ras proteins are members of the small G protein family. These proteins are characterized by a molecular weight between 20 and 30 kDa, the ability to bind GTP or GDP and a low intrinsic GTPase activity. These proteins relay signals from the plasma membrane activated by receptor tyrosine kinases to the nucleus via a network of serine/threonine kinases. Ras proteins belong to a family of approximately 40 mammalian and 60 non-mammalian proteins. Ras proteins were first discovered as the hyperactive products of mutant Ras genes which promote cancer by disrupting the normal controls on cell proliferation and differentiation; about 30% of human cancers have mutations in a Ras gene. |
Source : | E. Coli |
Species : | Human |
Tag : | GST |
Form : | Provided in 50mM Tris (pH 7.5) solution containing 150 mM NaCl, 10 mM MgCl2, 1 mM DTT, 10% glycerol |
Applications : | Affinity Binding; Rap1A protein is provided as a functional G-protein and can be used as a Western blot control for antibodies to Rap1A protein or in assays to study to protein-protein interactions of Rap1A and related proteins with regulatory proteins. |
Storage : | Product should be stored at -70°C. Aliquot to avoid freeze/thaw cycles |
Gene Name : | RAP1A RAP1A, member of RAS oncogene family [ Homo sapiens ] |
Official Symbol : | RAP1A |
Synonyms : | RAP1A; RAP1A, member of RAS oncogene family; ras-related protein Rap-1A; KREV 1; SMGP21; C21KG; G-22K; RAS-related protein RAP1A; Ras-related protein Krev-1; GTP-binding protein smg p21A; RAP1; KREV1; KREV-1; |
Gene ID : | 5906 |
mRNA Refseq : | NM_001010935 |
Protein Refseq : | NP_001010935 |
MIM : | 179520 |
UniProt ID : | P62834 |
Chromosome Location : | 1p13.3 |
Pathway : | ARMS-mediated activation, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class I PI3K signaling events, organism-specific biosystem; EPO signaling pathway, organism-specific biosystem; Focal Adhesion, organism-specific biosystem; |
Function : | GTP binding; GTPase activity; Ras GTPase binding; nucleotide binding; protein binding; |
Products Types
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Rap1a-443M | Recombinant Mouse Rap1a Protein, MYC/DDK-tagged | +Inquiry |
RAP1A-30502TH | Recombinant Human RAP1A, His-tagged | +Inquiry |
RAP1A-3784R | Recombinant Rhesus monkey RAP1A Protein, His-tagged | +Inquiry |
◆ Lysates | ||
RAP1A-2530HCL | Recombinant Human RAP1A 293 Cell Lysate | +Inquiry |
RAP1A-2529HCL | Recombinant Human RAP1A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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