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Recombinant Human CYCS, His-tagged

Cat.No. : CYCS-75H
Product Overview : Recombinant Human Cytochrome C/CYCS is produced with our E. coli expression system. The target protein is expressed with sequence (Gly2-Glu105) of Human CYCS fused with a 6His tag at the C-terminus.
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Description : Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as a central component of the electron transport chain in mitochondria. CYCS transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase). CYCS plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of Cytochrome C to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Source : E. coli
Species : Human
Tag : His
Form : Supplied as a 0.2 μM filtered solution of 20mM Tris, 0.15M NaCl, 20% Glycerol, pH 8.0
AA Sequence : MGDVEKGKKIFIMKCSQCHTVEKGG KHKTGPNLHGLFGRKTGQAPGYSYT AANKNKGIIWGEDTL MEYLENPKKYIPGTKMIFVGIKKKE ERADLIAYLKKATNELEHHHHHH
Endotoxin : Less than 0.1 ng/μg (1 IEU/μg).
Purity : Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Storage : Store at Please minimize freeze-thaw cycles.
Gene Name : CYCS cytochrome c, somatic [ Homo sapiens ]
Official Symbol : CYCS
Synonyms : CYCS; cytochrome c, somatic; cytochrome c; HCS; CYC; THC4;
Gene ID : 54205
mRNA Refseq : NM_018947
Protein Refseq : NP_061820
MIM : 123970
UniProt ID : P99999
Chromosome Location : 7p21.2
Pathway : Activation of caspases through apoptosome-mediated cleavage, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem;
Function : electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity; heme binding; metal ion binding; protein binding; contributes_to protein serine/threonine phosphatase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is the release of CYCS from mitochondria regulated? 12/07/2022

Bcl-2 family proteins regulate CYCS release, balancing pro- and anti-apoptotic signals.

What is the role of CYCS in apoptosis? 08/21/2022

In apoptosis, CYCS activates caspases after being released into the cytosol.

How does CYCS contribute to mitochondrial function? 04/16/2022

It transports electrons in the mitochondrial respiratory chain, aiding ATP production.

What happens when there is dysregulation in CYCS activity? 03/19/2022

Dysregulated CYCS activity can lead to impaired cellular energy production or excessive cell death.

What is the primary biological role of CYCS in cellular processes? 09/06/2021

CYCS is crucial for electron transport in mitochondria and inducing apoptosis.

How is CYCS implicated in various diseases? 03/28/2021

Alterations in CYCS are linked to various diseases, including neurodegenerative conditions and cancer.

Are there any therapeutic strategies targeting CYCS? 11/07/2018

Therapeutic strategies may aim to modulate CYCS activity, influencing apoptosis in diseases like cancer.

Customer Reviews (3)

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Reviews
05/07/2022

    Excellent for cell experiments.

    07/01/2021

      Good concentration, easy handling.

      12/03/2020

        Quick shipping, great condition.

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