Recombinant Human CYCS, His-tagged
Cat.No. : | CYCS-75H |
Product Overview : | Recombinant Human Cytochrome C/CYCS is produced with our E. coli expression system. The target protein is expressed with sequence (Gly2-Glu105) of Human CYCS fused with a 6His tag at the C-terminus. |
- Specification
- Gene Information
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Description : | Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as a central component of the electron transport chain in mitochondria. CYCS transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase). CYCS plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of Cytochrome C to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Supplied as a 0.2 μM filtered solution of 20mM Tris, 0.15M NaCl, 20% Glycerol, pH 8.0 |
AA Sequence : | MGDVEKGKKIFIMKCSQCHTVEKGG KHKTGPNLHGLFGRKTGQAPGYSYT AANKNKGIIWGEDTL MEYLENPKKYIPGTKMIFVGIKKKE ERADLIAYLKKATNELEHHHHHH |
Endotoxin : | Less than 0.1 ng/μg (1 IEU/μg). |
Purity : | Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. |
Storage : | Store at Please minimize freeze-thaw cycles. |
Gene Name : | CYCS cytochrome c, somatic [ Homo sapiens ] |
Official Symbol : | CYCS |
Synonyms : | CYCS; cytochrome c, somatic; cytochrome c; HCS; CYC; THC4; |
Gene ID : | 54205 |
mRNA Refseq : | NM_018947 |
Protein Refseq : | NP_061820 |
MIM : | 123970 |
UniProt ID : | P99999 |
Chromosome Location : | 7p21.2 |
Pathway : | Activation of caspases through apoptosome-mediated cleavage, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; |
Function : | electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity; heme binding; metal ion binding; protein binding; contributes_to protein serine/threonine phosphatase activity; |
Products Types
◆ Recombinant Protein | ||
CYCS-79M | Recombinant Mouse CYCS Protein, His-tagged | +Inquiry |
CYCS-2764H | Recombinant Human CYCS Protein, His (Fc)-Avi-tagged | +Inquiry |
CYCS-1368R | Recombinant Rat CYCS Protein, His (Fc)-Avi-tagged | +Inquiry |
CYCS-1296H | Recombinant Human CYCS Protein, His-tagged | +Inquiry |
Cycs-2406M | Recombinant Mouse Cycs Protein, Myc/DDK-tagged | +Inquiry |
◆ Native Protein | ||
CYTC-168E | Native Horse Cytochrome C | +Inquiry |
CYCS-17B | Native Bovine Cytochrome C Protein | +Inquiry |
◆ Lysates | ||
CYCS-7135HCL | Recombinant Human CYCS 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionBcl-2 family proteins regulate CYCS release, balancing pro- and anti-apoptotic signals.
In apoptosis, CYCS activates caspases after being released into the cytosol.
It transports electrons in the mitochondrial respiratory chain, aiding ATP production.
Dysregulated CYCS activity can lead to impaired cellular energy production or excessive cell death.
CYCS is crucial for electron transport in mitochondria and inducing apoptosis.
Alterations in CYCS are linked to various diseases, including neurodegenerative conditions and cancer.
Therapeutic strategies may aim to modulate CYCS activity, influencing apoptosis in diseases like cancer.
Customer Reviews (3)
Write a reviewExcellent for cell experiments.
Good concentration, easy handling.
Quick shipping, great condition.
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