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Active Recombinant Human BACE2, His-tagged

Cat.No. : BACE2-579TH
Product Overview : Recombinant soluble BACE2, cloned from human cDNA, secreted as zymogen from insect cells, purified using a C-terminal His-tag, and cleaved to the mature active form.
  • Specification
  • Gene Information
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Description : This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer''s disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants.
Source : insect cells
Species : Human
Tag : His
Form : Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 20% glycerol.
Bio-activity : >30 U/μg enzyme.
Molecular Mass : ~45kDa (calculated); ~48kDa (doublet by SDS-PAGE)
AA Sequence : aa Ala21-Pro466.
Purity : ≥80% (SDS-PAGE)
Applications : Study enzyme kinetics, cleave target substrates, and screen for BACE2 inhibitors or BACE1 inhibitor selectivity.
Stability : BACE2 is stable after 5 freeze-thaws at 0.3-0.4 µg/µl; freeze-thaw stability of more dilute preparations has not been tested and could lead to loss of activity.
Storage : -80°C
Gene Name : BACE2 beta-site APP-cleaving enzyme 2 [ Homo sapiens (human) ]
Official Symbol : BACE2
Synonyms : BACE2; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; beta-site APP-cleaving enzyme 2; beta-secretase 2; memapsin-1; theta-secretase; aspartyl protease 1; 56 kDa aspartic-like protease; Down syndrome region aspartic protease; transmembrane aspartic proteinase Asp1; membrane-associated aspartic protease 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; EC 3.4.23.45
Gene ID : 25825
mRNA Refseq : NM_012105
Protein Refseq : NP_036237
MIM : 605668
UniProt ID : Q9Y5Z0
Chromosome Location : 21q22.3
Pathway : Alzheimer''s disease
Function : aspartic-type endopeptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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