"BACE2" Related Products

Expand
Expand

Recombinant Human BACE2, His-tagged

Cat.No.: BACE2-579TH
Product Overview: Recombinant soluble BACE2, cloned from human cDNA, secreted as zymogen from insect cells, purified using a C-terminal His-tag, and cleaved to the mature active form.
Description: This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer''s disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants.
Source: insect cells
Species: Human
Tag: His
Form: Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 20% glycerol.
Bio-activity: >30 U/μg enzyme.
Molecular Mass: ~45kDa (calculated); ~48kDa (doublet by SDS-PAGE)
AA Sequence: aa Ala21-Pro466.
Purity: ≥80% (SDS-PAGE)
Applications: Study enzyme kinetics, cleave target substrates, and screen for BACE2 inhibitors or BACE1 inhibitor selectivity.
Stability: BACE2 is stable after 5 freeze-thaws at 0.3-0.4 µg/µl; freeze-thaw stability of more dilute preparations has not been tested and could lead to loss of activity.
Storage: -80°C
Gene Name: BACE2 beta-site APP-cleaving enzyme 2 [ Homo sapiens (human) ]
Official Symbol: BACE2
Synonyms: BACE2; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; beta-site APP-cleaving enzyme 2; beta-secretase 2; memapsin-1; theta-secretase; aspartyl protease 1; 56 kDa aspartic-like protease; Down syndrome region aspartic protease; transmembrane aspartic proteinase Asp1; membrane-associated aspartic protease 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; EC 3.4.23.45
Gene ID: 25825
mRNA Refseq: NM_012105
Protein Refseq: NP_036237
MIM: 605668
UniProt ID: Q9Y5Z0
Chromosome Location: 21q22.3
Pathway: Alzheimer''s disease
Function: aspartic-type endopeptidase activity

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.