"BACE2" Related Products


Recombinant Human BACE2, His-tagged

Cat.No. : BACE2-579TH
Product Overview : Recombinant soluble BACE2, cloned from human cDNA, secreted as zymogen from insect cells, purified using a C-terminal His-tag, and cleaved to the mature active form.
Description : This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer''s disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants.
Source : insect cells
Species : Human
Tag : His
Form : Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 20% glycerol.
Bio-activity : >30 U/μg enzyme.
Molecular Mass : ~45kDa (calculated); ~48kDa (doublet by SDS-PAGE)
AA Sequence : aa Ala21-Pro466.
Purity : ≥80% (SDS-PAGE)
Applications : Study enzyme kinetics, cleave target substrates, and screen for BACE2 inhibitors or BACE1 inhibitor selectivity.
Stability : BACE2 is stable after 5 freeze-thaws at 0.3-0.4 µg/µl; freeze-thaw stability of more dilute preparations has not been tested and could lead to loss of activity.
Storage : -80°C
Gene Name : BACE2 beta-site APP-cleaving enzyme 2 [ Homo sapiens (human) ]
Official Symbol : BACE2
Synonyms : BACE2; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; beta-site APP-cleaving enzyme 2; beta-secretase 2; memapsin-1; theta-secretase; aspartyl protease 1; 56 kDa aspartic-like protease; Down syndrome region aspartic protease; transmembrane aspartic proteinase Asp1; membrane-associated aspartic protease 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; EC
Gene ID : 25825
mRNA Refseq : NM_012105
Protein Refseq : NP_036237
MIM : 605668
UniProt ID : Q9Y5Z0
Chromosome Location : 21q22.3
Pathway : Alzheimer''s disease
Function : aspartic-type endopeptidase activity

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