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Recombinant Mouse Hbegf

Cat.No.: Hbegf-564M
Product Overview: Recombinant Mouse Hbegf produced in E. coli is approximately 9.8 KDa, a single non-glycosylated polypeptide chain containing 86 amino acids.
Description: Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins. HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein. An epidermal growth factor produced by monocytes and macrophages, due to an affinity for heparin is termed HB-EGF. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function. The transmembrane form of HB-EGF is the unique receptor for diptheria toxin and functions in juxtacrine signaling in cells. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis, organ hyperplasia, and atherosclerotic disease. HB-EGF can bind two locations on cell surfaces, heparan sulfate proteoglycans and EGF-receptor effecting cell to cell interactions.
Source: E. coli
Species: Mouse
Form: Lyophilized from a 0.2 μm filtered concentrated solution in 10 mM PB, 500 mM NaCl, pH7.4.
Bio-activity: Fully biologically active when compared to standard. The ED 50 determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 1 ng/ml, corresponding to a specific activity of >1.0 × 10^6 IU/mg.
Molecular Mass: 9.8 kDa
AA Sequence: DLEGTDLNLF KVAFSSKPQG LATPSKERNG KKKKKGKGLG KKRDPCLRKY KDYCIHGECR YLQEFRTPSC KCLPGYHGHR CHGLTL
Endotoxin: Less than 1 EU/μg of rMuHB-EGF as determined by LAL method.
Purity: >97% by SDS-PAGE and HPLC analyses.
Usage: This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage: This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles.
Reconstitution: We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name: Hbegf heparin-binding EGF-like growth factor [ Mus musculus ]
Official Symbol: Hbegf
Synonyms: HBEGF; heparin-binding EGF-like growth factor; proheparin-binding EGF-like growth factor; diphtheria toxin receptor; heparin binding epidermal growth factor-like growth factor; Dtr; Dts; Hegfl; AW047313; MGC107656;
Gene ID: 15200
mRNA Refseq: NM_010415
Protein Refseq: NP_034545
Pathway: ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem; GnRH signaling pathway, organism-specific biosystem; GnRH signaling pathway, conserved biosystem; Hypertrophy Model, organism-specific biosystem;
Function: epidermal growth factor receptor binding; epidermal growth factor receptor binding; eukaryotic cell surface binding; growth factor activity; growth factor activity; heparin binding; heparin binding;

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