"Il4" Related Products

Recombinant Rat Il4

Cat.No.: Il4-577R
Product Overview: Recombinant Rat Il4 produced in E. coli is approximately 14.0 kDa, a single non-glycosylated polypeptide chain containing 125 amino acids.
Description: Interleukin-4 (IL-4) is a pleiotropic cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells and produced by mast cells, activated T cells and bone marrow stromal cells. It has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4 + T-cells into Th2 cells. IL-4 can enhance both secretion and cell surface expression of IgE and IgG1 and also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. The rat IL-4 shares about 40 %~45 % a.a. sequence identity with human, mouse, rhesus macaque IL-4 and they are species-specific in their activities.
Source: E. coli
Species: Rat
Form: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4, 5% trehalose.
Bio-activity: Fully biologically active when compared to standard. The ED 50 determined by a cell proliferation assay using rat splenocytes is less than 1.5 ng/ml, corresponding to a specific activity of >6.7 × 10^6 IU/mg.
Molecular Mass: 14 kDa
AA Sequence: HGCNDSPLRE IINTLNQVTE KGTPCTEMFV PDVLTATRNT TENELICRAS RVLRKFYFPR DVPPCLKNKS GVLGELRKLC RGVSGLNSLR SCTVNESTLT TLKDFLESLK SILRGKYLQS CTSMS
Endotoxin: Less than 1 EU/μg of rRtIL-4 as determined by LAL method.
Purity: >97% by SDS-PAGE and HPLC analyses.
Usage: This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage: This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles.
Reconstitution: We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name: Il4 interleukin 4 [ Rattus norvegicus ]
Official Symbol: Il4
Synonyms: IL4; interleukin 4; interleukin-4; IL-4; BSF-1; B-cell growth factor 1; B-cell stimulatory factor 1; lymphocyte stimulatory factor 1; B-cell IGG differentiation factor; Il4e12;
Gene ID: 287287
mRNA Refseq: NM_201270
Protein Refseq: NP_958427
Pathway: Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem;
Function: cytokine activity; cytokine activity; growth factor activity; interleukin-4 receptor binding;

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