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Recombinant Rat Igf1

Cat.No.: Igf1-590R
Product Overview: Recombinant Rat Igf1 produced in E. coli is approximately 7.7 kDa, a single non-glycosylated polypeptide chain containing 70 amino acid residues.
Description: Insulinlike growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. It shares 61% aa sequence identity with mature rat IGF-II. Circulating IGF-I is produced by hepatocytes, while local IGF-I is produced by many other tissues in which it has paracrine effects. IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally.
Source: E. coli
Species: Rat
Form: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Bio-activity: Fully biologically active when compared to standard. The ED 50 determined by a cell proliferation assay using serum free human MCF-7 cells is less than 3 ng/ml, corresponding to a specific activity of >3.3 × 10^5 IU/mg.
Molecular Mass: 7.7 kDa
AA Sequence: GPETLCGAEL VDALQFVCGP RGFYFNKPTG YGSSIRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPTKSA
Endotoxin: Less than 1 EU/μg of rRtIGF-1 as determined by LAL method.
Purity: >97% by SDS-PAGE and HPLC analyses.
Usage: This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage: This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles.
Reconstitution: We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name: Igf1 insulin-like growth factor 1 [ Rattus norvegicus ]
Official Symbol: Igf1
Synonyms: IGF1; insulin-like growth factor 1; insulin-like growth factor I; IGF-I; somatomedin;
Gene ID: 24482
mRNA Refseq: NM_001082477
Protein Refseq: NP_001075946
Pathway: Adipogenesis, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Dilated cardiomyopathy, organism-specific biosystem;
Function: growth factor activity; hormone activity; hormone activity; insulin receptor binding; insulin-like growth factor receptor binding; insulin-like growth factor receptor binding; integrin binding; protein binding; protein serine/threonine kinase activator ac

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