"RPS6KA3" Related Products

Recombinant Human RPS6KA3, GST-tagged

Cat.No. : RPS6KA3-153H
Product Overview : Recombinant full-length human RSK2 (I416V) mutant was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : RSK2 is a member of the RSK (ribosomal S6 kinase) family that consists of growth factor-regulated serine/threonine kinases. RSK2 has been shown to mediate growth factor signaling via RAS and MAPK leading to the induction of CREB serine-133 phosphorylation and activation of gene expression. Mutations in RSK2 have been shown to be responsible for Coffin-Lowry syndrome (CLS) which is a X-linked disorder characterized by severe psychomotor retardation, facial and digital dysmorphisms, and progressive skeletal deformations.
Source : Sf9 insect cells using baculovirus
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : The specific activity of RSK2 (I416V) was determined to be 62 nmol /min/mg
Molecular Mass : ~112 kDa
Purity : >95% by densitometry
Applications : Kinase Assay, Western Blot
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 μg/μl
Gene Name : RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [ Homo sapiens ]
Official Symbol : RPS6KA3
Synonyms : RPS6KA3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; CLS, Coffin Lowry syndrome , mental retardation, X linked 19 , MRX19, ribosomal protein S6 kinase, 90kD, polypeptide 3; ribosomal protein S6 kinase alpha-3; HU 3; RSK; RSK2; RSK-2; p90-RSK 3; MAPKAPK-1b; S6K-alpha-3; MAPKAP kinase 1b; ribosomal S6 kinase 2; MAPK-activated protein kinase 1b; insulin-stimulated protein kinase 1; MAP kinase-activated protein kinase 1b; CLS; HU-3; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3;
Gene ID : 6197
mRNA Refseq : NM_004586
Protein Refseq : NP_004577
MIM : 300075
UniProt ID : P51812
Chromosome Location : Xp22.2-p22.1
Pathway : Activated TLR4 signalling, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Axon guidance, organism-specific biosystem; CREB phosphorylation, organism-specific biosystem; CREB phosphorylation through the activation of Ras, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem; Cytoplasmic Ribosomal Proteins, organism-specific biosystem;
Function : ATP binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; magnesium ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity;

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