"TET2" Related Products

Recombinant Human TET2, GST-tagged

Cat.No.: TET2-160H
Product Overview: Recombinant human TET2 (1197-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: TET2 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine which is involved in myelopoiesis. Defects in TET2 gene have been associated with several myeloproliferative disorders. TET2 play an important role in embryonic stem cell maintenance and inner cell mass cell specification. TET proteins have potential roles in epigenetic regulation through modification of 5mC to 5hmC. TET2 enzymatic activity is involved in myeloid tumorigenesis and this could be valuable as a diagnostic and prognostic tool for targeted therapies and to assess responses to anticancer drugs.
Source: Sf9 insect cells using baculovirus
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass: ~124 kDa
Purity: >70% by densitometry
Applications: Western Blot
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1 μg/μl
Gene Name: TET2 tet methylcytosine dioxygenase 2 [ Homo sapiens ]
Official Symbol: TET2
Synonyms: TET2; tet methylcytosine dioxygenase 2; KIAA1546 , tet oncogene family member 2; methylcytosine dioxygenase TET2; FLJ20032; tet oncogene family member 2; probable methylcytosine dioxygenase TET2; MDS; KIAA1546; MGC125715;
Gene ID: 54790
mRNA Refseq: NM_001127208
Protein Refseq: NP_001120680
MIM: 612839
UniProt ID: Q6N021
Chromosome Location: 4q24
Function: metal ion binding; methylcytosine dioxygenase activity; methylcytosine dioxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;

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