Recombinant Mouse Bmp2k, GST-tagged

• Cat.No.: Bmp2k-225M
• Product Overview: Recombinant mouse BMP2K (1-422) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: BMP2K or Bone morphogenic protein 2 inducible kinase is the human homolog of mouse BMP-2-inducible kinase which plays a key role in skeletal development and patterning. BMP2K is a serine/threonine protein kinase which contains a nuclear localization signal and plays a regulatory role in attenuating the program of osteoblast differentiation. BMP2K gene is strongly correlated with high myopia and may contribute to a genetic risk factor for high degrees of myopic pathogenesis. BMP-2 expression is suppressed by an EP4 receptor antagonist and PGE2 produced by COX-2 increases BMP-2 expression via binding the EP4 receptor.
• Source: Sf9 insect cells using baculovirus
• Species: Mouse
• Tag: GST
• Form: Recombinant protein stored in 50mM is-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~70 kDa
• Purity: >95% by densitometry
• Applications: Western Blot
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μl

Gene Information

• Gene Name: Bmp2k BMP2 inducible kinase [ Mus musculus ]
• Official Symbol: Bmp2k
• Synonyms: BMP2K; BMP2 inducible kinase; BMP-2-inducible protein kinase; BIKE; AA673486; AV128808; 4933417M22Rik
• Gene ID: 140780
• mRNA Refseq: NM_080708
• Protein Refseq: NP_542439
• Pathway: Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem
• Function: ATP binding; kinase activity; nucleotide binding; phosphatase regulator activity; protein kinase activity; protein serine/threonine kinase activity; transferase activity; transferase activity, transferring phosphorus-containing groups