Recombinant Human ANXA5, GST-tagged

• Cat.No.: ANXA5-112H
• Product Overview: Recombinant human annexin V fused to a GST-tag.

Specification

• Description: Annexin V is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Annexin V competes for phosphatidylserine binding sites (e.g. platelets) with prothrombin or coagulation factors and inhibis the activity of phospholipase A1. Antibodies directed against annexin V are found in patients with a disease called the antiphospholipid syndrome(APS), a thrombophilic disease associated with autoantibodies against phospholipid compounds. Annexin V is used as a probe in the "annexin V affinity assay" to detect cells that have expressed phosphatidylserine on the cell surface, a feature found in apoptosis and other forms of cell death.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: Lyophilized. In PBS, pH 7.4.
• Molecular Mass: ~52kDa (SDS-PAGE)
• Purity: Affinity purified.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Reconstituted solutions can be kept at 4°C under sterile conditions for one week or should be frozen in aliquots at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles. Repeated freeze/thaw cycles (>3) may result in an adverse effect on the activity.

Gene Information

• Gene Name: ANXA5 annexin A5 [ Homo sapiens ]
• Official Symbol: ANXA5
• Synonyms: ANXA5; annexin A5; ANX5, ENX2; CBP-I; PAP-I; VAC-alpha; annexin V; annexin-5; anchorin CII; endonexin II; lipocortin V; calphobindin I; thromboplastin inhibitor; vascular anticoagulant-alpha; placental anticoagulant protein 4; placental anticoagulant protein I; PP4; ANX5; ENX2
• Gene ID: 308
• mRNA Refseq: NM_001154
• Protein Refseq: NP_001145
• MIM: 131230
• UniProt ID: P08758
• Chromosome Location: 4q27
• Pathway: Prostaglandin Synthesis and Regulation, organism-specific biosystem
• Function: calcium ion binding; calcium-dependent phospholipid binding; eukaryotic cell surface binding; phospholipase inhibitor activity; phospholipid binding; receptor tyrosine kinase binding