Active Recombinant Mouse Crebbp, His-tagged
Cat.No. : | Crebbp-168M |
Product Overview : | Mouse CREB-binding protein fused at the C-terminus to a His-tag. |
- Specification
- Gene Information
- Related Products
Description : | CREB-binding protein acetylates histones, giving a specific tag for transcriptional activation. It also acetylates non-histone proteins, like NCOA3 and FOXO1. It binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. |
Source : | Baculovirus infected Sf21 Cells |
Species : | Mouse |
Tag : | His |
Form : | Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50-100mM imidazole and 10% glycerol. |
Bio-activity : | ~50-100ng are required for standard HAT assay. |
Purity : | ≥95% (SDS-PAGE) |
Stability : | Stable for at least 6 months after receipt when stored at -80°C. |
Storage : | Short Term Storage: -20°C; Long Term Storage: -80°C. After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles. |
Concentration : | Lot dependent (0.2-0.5mg/ml) |
Gene Name : | Crebbp CREB binding protein [ Mus musculus ] |
Official Symbol : | Crebbp |
Synonyms : | CREBBP; CREB binding protein; CREB-binding protein; CBP; KAT3A; AW558298; CBP/p300; p300/CBP; |
Gene ID : | 12914 |
mRNA Refseq : | NM_001025432 |
Protein Refseq : | NP_001020603 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Cell cycle signaling pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem; |
Function : | DNA binding; MyoD binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II transcription factor binding; RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription; SMAD binding; acetyltransferase activity; acetyltransferase activity; activating transcription factor binding; chromatin binding; core promoter proximal region sequence-specific DNA binding; histone acetyltransferase activity; histone acetyltransferase activity; metal ion binding; p53 binding; peroxisome proliferator activated receptor binding; protein binding; contributes_to sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription coactivator activity; transcription cofactor activity; transcription factor binding; transcription factor binding; transferase activity; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
CREBBP-01D | Recombinant Dog Crebbp Protein, His tagged | +Inquiry |
CREBBP-22HCL | Recombinant Human CREBBP 293 Cell Lysate | +Inquiry |
CREBBP-1022R | Recombinant Monkey Crebbp Protein, His tagged | +Inquiry |
CREBBP-001H | Recombinant Human CREBBP Protein, GST-tagged | +Inquiry |
CREBBP-847R | Recombinant Rhesus Macaque CREBBP Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Assay kits | ||
Kit-1710 | CREBBP Inhibitor Screening Assay Kit | +Inquiry |
Kit-1711 | CREBBP TR-FRET Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionDiscovering novel CREBBP inhibitors is crucial due to the limited number of reported inhibitors, and there is a need to enhance the activity and selectivity of existing compounds.
The bromodomain in CREBBP is linked to its involvement in cancer and other disease processes.
CREBBP stands for CREB-binding protein.
CREBBP serves as a coactivator for the cAMP response element-binding protein (CREB) transcription factor. It plays a crucial role in gene activation.
Research on small molecule inhibitors of CREBBP is in its early stages, with only a few inhibitors reported. Improvements in activity and selectivity are needed for these compounds.
CREBBP belongs to the third category of structural domain proteins, and it shares homology with its counterpart EP300.
CREBBP contains a bromodomain, which is associated with the development of cancer and other diseases.
Customer Reviews (3)
Write a reviewThe product's adaptability to custom protocols empowered us to explore innovative experimental setups.
The reduced environmental impact of the product was a responsible choice that resonated with our values.
Customized solutions offered by the manufacturer increased the product's utility in our research.
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