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Active Recombinant Mouse Crebbp, His-tagged

Cat.No. : Crebbp-168M
Product Overview : Mouse CREB-binding protein fused at the C-terminus to a His-tag.
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  • Gene Information
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Description : CREB-binding protein acetylates histones, giving a specific tag for transcriptional activation. It also acetylates non-histone proteins, like NCOA3 and FOXO1. It binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.
Source : Baculovirus infected Sf21 Cells
Species : Mouse
Tag : His
Form : Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50-100mM imidazole and 10% glycerol.
Bio-activity : ~50-100ng are required for standard HAT assay.
Purity : ≥95% (SDS-PAGE)
Stability : Stable for at least 6 months after receipt when stored at -80°C.
Storage : Short Term Storage: -20°C; Long Term Storage: -80°C. After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles.
Concentration : Lot dependent (0.2-0.5mg/ml)
Gene Name : Crebbp CREB binding protein [ Mus musculus ]
Official Symbol : Crebbp
Synonyms : CREBBP; CREB binding protein; CREB-binding protein; CBP; KAT3A; AW558298; CBP/p300; p300/CBP;
Gene ID : 12914
mRNA Refseq : NM_001025432
Protein Refseq : NP_001020603
Pathway : Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Cell cycle signaling pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem;
Function : DNA binding; MyoD binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II transcription factor binding; RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription; SMAD binding; acetyltransferase activity; acetyltransferase activity; activating transcription factor binding; chromatin binding; core promoter proximal region sequence-specific DNA binding; histone acetyltransferase activity; histone acetyltransferase activity; metal ion binding; p53 binding; peroxisome proliferator activated receptor binding; protein binding; contributes_to sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription coactivator activity; transcription cofactor activity; transcription factor binding; transcription factor binding; transferase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Why is the discovery of new CREBBP inhibitors urgent? 07/20/2022

Discovering novel CREBBP inhibitors is crucial due to the limited number of reported inhibitors, and there is a need to enhance the activity and selectivity of existing compounds.

What is the significance of the bromodomain in CREBBP? 06/27/2022

The bromodomain in CREBBP is linked to its involvement in cancer and other disease processes.

What does CREBBP stand for? 08/25/2020

CREBBP stands for CREB-binding protein.

What is the role of CREBBP in cellular function? 03/19/2019

CREBBP serves as a coactivator for the cAMP response element-binding protein (CREB) transcription factor. It plays a crucial role in gene activation.

What is the current status of CREBBP small molecule inhibitors? 04/03/2016

Research on small molecule inhibitors of CREBBP is in its early stages, with only a few inhibitors reported. Improvements in activity and selectivity are needed for these compounds.

In which category of structural domain proteins does CREBBP belong? 02/14/2016

CREBBP belongs to the third category of structural domain proteins, and it shares homology with its counterpart EP300.

How many structural domains does CREBBP have? 02/01/2016

CREBBP contains a bromodomain, which is associated with the development of cancer and other diseases.

Customer Reviews (3)

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Reviews
04/17/2021

    The product's adaptability to custom protocols empowered us to explore innovative experimental setups.

    01/29/2019

      The reduced environmental impact of the product was a responsible choice that resonated with our values.

      11/15/2016

        Customized solutions offered by the manufacturer increased the product's utility in our research.

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