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Recombinant Human FASLG, Fc-tagged
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Cat.No. : | FASLG-245H |
Product Overview : | Human FasL (aa 139-281) is fused at the N-terminus to the Fc portion of human IgG1. |
Description : | Fc (human):FasL, Soluble (human) is a high activity construct in which two trimeric FasL are artificially linked via the Fc binding domain of human IgG1. This construct very effectively simulates the natural membrane-assisted aggregation of FasL in vivo. FasL is a cytokine that binds to TNFRSF6/Fas, a receptor that transduces the apoptotic signal into cells. It is involved in cytotoxic T cell mediated apoptosis and in T cell development. |
Source : | HEK293 Cells |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized. Contains PBS. |
Bio-activity : | Induces apoptosis of human Jurkat T cells at a concentration of<0.2ng l.>0.2ng> |
Molecular Mass : | ~50kDa (SDS-PAGE) |
Purity : | ≥95% (SDS-PAGE) |
Stability : | Stable for at least 6 months after receipt when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions. |
Concentration : | 0.1mg/ml after reconstitution. |
Gene Name : | FASLG Fas ligand (TNF superfamily, member 6) [ Homo sapiens ] |
Official Symbol : | FASLG |
Synonyms : | FASLG; Fas ligand (TNF superfamily, member 6); APT1LG1, TNFSF6, tumor necrosis factor (ligand) superfamily, member 6; tumor necrosis factor ligand superfamily member 6; CD178; FasL; APTL; CD95 ligand; fas antigen ligand; apoptosis antigen ligand; apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand) superfamily, member 6; FASL; CD95L; CD95-L; TNFSF6; APT1LG1; |
Gene ID : | 356 |
mRNA Refseq : | NM_000639 |
Protein Refseq : | NP_000630 |
MIM : | 134638 |
UniProt ID : | P48023 |
Chromosome Location : | 1q23 |
Pathway : | Activation of Pro-Caspase 8, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; |
Function : | cytokine activity; protein binding; receptor binding; tumor necrosis factor receptor binding; |
◆ Recombinant Protein
FASLG-5412H | Recombinant Human Fas Ligand (TNF superfamily, member 6), His-tagged | +Inquiry |
Faslg-372M | Recombinant Mouse Faslg Protein, His-tagged | +Inquiry |
Faslg-373R | Recombinant Rat Faslg Protein, His-tagged | +Inquiry |
FASLG-1394H | Recombinant Human FASLG Protein (103-281 aa), His-tagged | +Inquiry |
FASLG-5413H | Recombinant Human Fas Ligand (TNF superfamily, member 6) | +Inquiry |
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◆ Lysates
FASLG-6324HCL | Recombinant Human FASLG 293 Cell Lysate | +Inquiry |
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