Recombinant Human IL37, His-tagged

• Cat.No.: IL37-370H
• Product Overview: Human IL-37 (aa Val46-Asp218) is fused at the C-terminus to a His-tag.

Specification

• Description: IL-37 (IL-1F7; IL-1H4) belongs to the IL-1 family of proteins. It binds to the interleukin-18 receptor (IL-18R) but not to the IL-1 receptor. It plays an important role as a link between innate and adaptive immunity. IL-37 is a new player in inflammatory and immune responses, mediated by the IL-18/IL-18R axis. It was shown to inhibit tumor growth.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized from 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.
• Molecular Mass: ~20kDa (SDS-PAGE)
• Endotoxin: <0.1eu g purified protein (lal test; lonza).>
• Purity: ≥95% (SDS-PAGE)
• Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: IL37 interleukin 37 [ Homo sapiens ]
• Official Symbol: IL37
• Synonyms: IL37; interleukin 37; IL1F7, interleukin 1 family, member 7 (zeta); interleukin-37; FIL1; FIL1(ZETA); FIL1Z; IL 1F7; IL 1H4; IL 1RP1; interleukin 1; zeta; interleukin 1 homolog 4; interleukin 1 related protein; FIL1 zeta; IL-1 zeta; IL-1X protein; interleukin-23; interleukin 1, zeta; interleukin-1 homolog 4; interleukin-1 superfamily z; interleukin 1 family member 7; interleukin-1-related protein; IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL1F7 (canonical product IL-1F7b); IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1
• Gene ID: 27178
• mRNA Refseq: NM_014439
• Protein Refseq: NP_055254
• MIM: 605510
• UniProt ID: Q9NZH6
• Chromosome Location: 2q12-q14.1
• Function: cytokine activity; interleukin-1 receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 receptor binding