"JAG2" Related Products


Recombinant Human JAG2, Fc-tagged

Cat.No.: JAG2-382H
Product Overview: Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG.
Description: Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappa;B and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.
Source: HEK293 Cells
Species: Human
Tag: Fc
Form: Liquid. 0.2μm-filtered solution in PBS.
Molecular Mass: ~150kDa (SDS-PAGE)
Purity: ≥90% (SDS-PAGE)
Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Concentration: 0.2mg/ml
Gene Name: JAG2 jagged 2 [ Homo sapiens ]
Official Symbol: JAG2
Synonyms: JAG2; jagged 2; protein jagged-2; HJ2; SER2;
Gene ID: 3714
mRNA Refseq: NM_002226
Protein Refseq: NP_002217
MIM: 602570
UniProt ID: Q9Y219
Chromosome Location: 14q32
Pathway: Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, conserved biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem;
Function: Notch binding; calcium ion binding; growth factor activity; protein binding;

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