"TRIM21" Related Products


Recombinant Human TRIM21, MYC/DDK-tagged

Cat.No.: TRIM21-105H
Product Overview: Recombinant Human TRIM21 fused with C-terminal MYC/DDK, was expressed in HEK293 Cells.
Description: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
Source: HEK293 Cells
Species: Human
Molecular Mass: 54 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Storage: Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Concentration: >50 ug/mL as determined by microplate BCA method
Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name: TRIM21 tripartite motif containing 21 [ Homo sapiens (human) ]
Official Symbol: TRIM21
Synonyms: TRIM21; SSA; RO52; SSA1; RNF81; tripartite motif containing 21; E3 ubiquitin-protein ligase TRIM21; SS-A; ro(SS-A); 52 kDa Ro protein; RING finger protein 81; Sicca syndrome antigen A; tripartite motif-containing 21; sjoegren syndrome type A antigen; tripartite motif-containing protein 21; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)
Gene ID: 6737
mRNA Refseq: NM_003141
Protein Refseq: NP_003132
MIM: 109092
UniProt ID: P19474
Chromosome Location: 11p15.5
Pathway: Adaptive Immune System; Antigen processing: Ubiquitination & Proteasome degradation; Cytosolic sensors of pathogen-associated DNA
Function: DNA binding; RNA binding; ubiquitin-protein ligase activity

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