Active Recombinant Human TLR1, Fc-tagged

• Cat.No.: TLR1-686H
• Product Overview: Recombinant Human TLR1(Ser22 - Asn578) was expressed in Mouse NSO Cells.

Specification

• Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Fc
• Predicted N Terminal: Ser22
• Form: Lyophilized from a 0.2 µm filtered solution in PBS.
• Bio-activity: Measured by its ability to bind biotinylated Pam3CysSerLys4 (PAM3CSK4).
• Molecular Mass: Predicted Molecular Mass:89.9 kDaSDS-PAGE:95-105 kDa, reducing conditions
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 °C as supplied.1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Reconstitution: Reconstitute at 100 µg/mL in PBS.

Gene Information

• Gene Name: TLR1 toll-like receptor 1 [ Homo sapiens (human) ]
• Official Symbol: TLR1
• Synonyms: TLR1; TIL; CD281; rsc786; TIL. LPRS5; toll-like receptor 1; toll-like receptor 1; toll/interleukin-1 receptor-like protein
• Gene ID: 7096
• mRNA Refseq: NM_003263
• Protein Refseq: NP_003254
• MIM: 601194
• UniProt ID: Q15399
• Chromosome Location: 4p14
• Pathway: Activated TLR4 signalling; Immune System; MyD88:Mal cascade initiated on plasma membrane
• Function: protein heterodimerization activity; receptor activity; transmembrane signaling receptor activity