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Recombinant Human SOST, His-tagged, Biotinylated

Cat.No.: SOST-270H
Product Overview: Human Sclerostin /SOST Protein, Biotinylated (Biotinylated SOST) Gln 24 - Tyr 213, was labeled with biotin based on rhSOST Protein, which was produced in human 293 cells (HEK293).
Description: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Source: HEK293
Species: Human
Tag: His
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose are added as protectants before lyophilization.
Molecular Mass: Biotinylated SOST, fused with 6×His tag at the N-terminus, has a calculated MW of 22.5 kDa. The predicted N-terminus is Gln 24. DTT-reduced Protein migrates as 28 kDa due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the Biotinylated SOST by the LAL method.
Purity: >95% as determined by reduced SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).
Gene Name: SOST sclerostin [ Homo sapiens ]
Official Symbol: SOST
Synonyms: SOST; sclerostin; sclerosteosis; VBCH;
Gene ID: 50964
mRNA Refseq: NM_025237
Protein Refseq: NP_079513
MIM: 605740
UniProt ID: Q9BQB4
Chromosome Location: 17q12-q21
Function: heparin binding; protein binding; transcription factor binding;

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