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Recombinant Human FASLG, C13&N15-labeled

Cat.No.: FASLG-234H
Product Overview: Recombinant Human Fas Ligand MS Standard Protein, C13 and N15-labeled (Fas Ligand, Heavy Labeled) Pro 134 - Leu 281 (Accession # AAH17502.1) was produced in human 293 cells (HEK293).
Description: Fas ligand also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.[1-3]
Source: HEK293
Species: Human
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: Fas Ligand, Heavy Labeled, fused with 6×His tag at the N-terminus, has a calculated MW of 17.7 kDa. The predicted N-terminus is Pro 134 . DTT-reduced Protein migrates as 25-32 kDa due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the Fas Ligand, Heavy Labeled by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC-8oC); After reconstitution under sterile conditions for 1 month (4oC-8oC) or 3 months (-20oC to -70oC).
Gene Name: FASLG Fas ligand (TNF superfamily, member 6) [ Homo sapiens ]
Official Symbol: FASLG
Synonyms: FASLG; Fas ligand (TNF superfamily, member 6); APT1LG1, TNFSF6, tumor necrosis factor (ligand) superfamily, member 6; tumor necrosis factor ligand superfamily member 6; CD178; FasL; APTL; CD95 ligand; fas antigen ligand; apoptosis antigen ligand; apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand) superfamily, member 6; FASL; CD95L; CD95-L; TNFSF6; APT1LG1;
Gene ID: 356
mRNA Refseq: NM_000639
Protein Refseq: NP_000630
MIM: 134638
UniProt ID: P48023
Chromosome Location: 1q23
Pathway: Activation of Pro-Caspase 8, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem;
Function: cytokine activity; protein binding; receptor binding; tumor necrosis factor receptor binding;

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