Recombinant Human SIRT7, Flag-tagged


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Recombinant Human SIRT7, Flag-tagged

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Cat.No. : SIRT7-12H
Product Overview : Recombinant Human SIRT7, fused with C-terminal Flag tag, was expressed in an E. coli cell expression system.
Description : This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Source : E. coli
Species : Human
Tag : Flag
Form : 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl and 10% glycerol.
Molecular Mass : 46 kDa
Purity : ≥60%
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Stability : >6 months at –80°C
Gene Name : SIRT7 sirtuin 7 [ Homo sapiens (human) ]
Official Symbol : SIRT7
Synonyms : SIRT7; SIR2L7; sirtuin 7; NAD-dependent protein deacetylase sirtuin-7; sirtuin type 7; SIR2-like protein 7; sir2-related protein type 7; regulatory protein SIR2 homolog 7; NAD-dependent deacetylase sirtuin-7; silent mating type information regulation 2, S.cerevisiae, homolog 7; NP_057622.1; EC 3.5.1.-
Gene ID : 51547
mRNA Refseq : NM_016538
Protein Refseq : NP_057622
MIM : 606212
UniProt ID : Q9NRC8
Chromosome Location : 17q25
Pathway : Signaling events mediated by HDAC Class I; Signaling events mediated by HDAC Class III
Function : NAD+ binding; NAD-dependent histone deacetylase activity (H3-K18 specific); chromatin binding

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