"SIRT7" Related Products


Recombinant Human SIRT7, Flag-tagged

Cat.No.: SIRT7-12H
Product Overview: Recombinant Human SIRT7, fused with C-terminal Flag tag, was expressed in an E. coli cell expression system.
Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Source: E. coli
Species: Human
Tag: Flag
Form: 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl and 10% glycerol.
Molecular Mass: 46 kDa
Purity: ≥60%
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Stability: >6 months at –80°C
Gene Name: SIRT7 sirtuin 7 [ Homo sapiens (human) ]
Official Symbol: SIRT7
Synonyms: SIRT7; SIR2L7; sirtuin 7; NAD-dependent protein deacetylase sirtuin-7; sirtuin type 7; SIR2-like protein 7; sir2-related protein type 7; regulatory protein SIR2 homolog 7; NAD-dependent deacetylase sirtuin-7; silent mating type information regulation 2, S.cerevisiae, homolog 7; NP_057622.1; EC 3.5.1.-
Gene ID: 51547
mRNA Refseq: NM_016538
Protein Refseq: NP_057622
MIM: 606212
UniProt ID: Q9NRC8
Chromosome Location: 17q25
Pathway: Signaling events mediated by HDAC Class I; Signaling events mediated by HDAC Class III
Function: NAD+ binding; NAD-dependent histone deacetylase activity (H3-K18 specific); chromatin binding

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