Recombinant Human SIRT7, Flag-tagged

• Cat.No.: SIRT7-12H
• Product Overview: Recombinant Human SIRT7, fused with C-terminal Flag tag, was expressed in an E. coli cell expression system.

Specification

• Species: Human
• Source: E.coli
• Tag: Flag
• Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
• Form: 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl and 10% glycerol.
• Molecular Mass: 46 kDa
• Purity: ≥60%
• Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Stability: >6 months at –80°C

Gene Information

• Gene Name: SIRT7 sirtuin 7 [ Homo sapiens (human) ]
• Official Symbol: SIRT7
• Synonyms: SIRT7; SIR2L7; sirtuin 7; NAD-dependent protein deacetylase sirtuin-7; sirtuin type 7; SIR2-like protein 7; sir2-related protein type 7; regulatory protein SIR2 homolog 7; NAD-dependent deacetylase sirtuin-7; silent mating type information regulation 2, S.cerevisiae, homolog 7; NP_057622.1; EC 3.5.1.-
• Gene ID: 51547
• mRNA Refseq: NM_016538
• Protein Refseq: NP_057622
• MIM: 606212
• UniProt ID: Q9NRC8
• Chromosome Location: 17q25
• Pathway: Signaling events mediated by HDAC Class I; Signaling events mediated by HDAC Class III
• Function: NAD+ binding; NAD-dependent histone deacetylase activity (H3-K18 specific); chromatin binding