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Recombinant human NEFL

Cat.No. : NEFL-182H
Product Overview : E. coli
  • Specification
  • Gene Information
  • Related Products
Description : Protein standard for immunoblotting, immunization and immunoassays.
Source : E. coli
Species : Human
Form : lyophilized, purified
Purity : >98%
Storage : At 2-8 centigrade (lyoph.); at -20 centigrade (reconstituted)
Gene Name : NEFL neurofilament, light polypeptide [ Homo sapiens ]
Official Symbol : NEFL
Synonyms : NEFL; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; neurofilament light polypeptide; CMT1F; CMT2E; NF68; NFL; neurofilament subunit NF-L; neurofilament triplet L protein; neurofilament protein, light chain; light molecular weig
Gene ID : 4747
mRNA Refseq : NM_006158
Protein Refseq : NP_006149
MIM : 162280
UniProt ID : P07196
Chromosome Location : 8p21.2
Pathway : Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; CREB phosphorylation through the activation of CaMKII, organism-specific biosystem; CREB phosphorylation through the activation of Ras, organism-specific biosystem; Neuronal System, organism-specific biosystem; Neurotransmitter Receptor Binding And Downstream Transmission In ThePostsynaptic Cell, organism-specific biosystem;
Function : identical protein binding; protein C-terminus binding; protein binding; structural constituent of cytoskeleton;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the relationship between NEFL and neurofilaments? 02/26/2021

NEFL is the light chain subunit of neurofilaments, crucial for their assembly and function.

How does NEFL contribute to the stability and structure of axons? 08/01/2020

It is a major component of neurofilaments, providing stability and support to axons.

Are there known genetic mutations in NEFL associated with specific neurological conditions? 12/21/2019

Genetic mutations in NEFL have been linked to Charcot-Marie-Tooth disease and other neuropathies.

What is the primary function of NEFL in neuronal cells? 04/05/2019

NEFL plays a crucial role in maintaining the structure and function of neuronal axons.

In which cells or tissues is NEFL predominantly expressed? 12/17/2018

NEFL is predominantly expressed in neurons, particularly in the axons.

What therapeutic strategies are being explored involving NEFL for neurodegenerative diseases? 07/27/2018

Therapeutic strategies are being developed to target NEFL aggregation and dysfunction in neurodegenerative diseases.

How is NEFL implicated in neurodegenerative diseases? 05/13/2018

Abnormal accumulation of NEFL is associated with various neurodegenerative diseases.

Customer Reviews (3)

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Reviews
11/30/2022

    Worked well, fast shipping.

    06/06/2022

      Satisfied with the quality.

      02/16/2022

        Excellent product, very satisfied.

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