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Recombinant Human CD163, His-tagged

Cat.No.: CD163-112H
Product Overview: Recombinant Human CD163 (Gly41-Ser1045), fused with a C-terminal 10-His tag, was expressed in NSO Cells.
Description: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Source: NSO Cells
Species: Human
Tag: His
Predicted N Terminal: Gly41
Form: Lyophilized from a 0.2 μm filtered solution in PBS.
Bio-activity: Measured by its ability to bind Haptoglobin/Hemoglobin (Hp/Hb) complexes.
Molecular Mass: Predicted Molecular Mass: 110 kDaSDS-PAGE: 135-140 kDa, reducing conditions
Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage: Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 °C as supplied.1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution: Reconstitute at 250 μg/mL in sterile PBS.
Gene Name: CD163 CD163 molecule [ Homo sapiens (human) ]
Official Symbol: CD163
Synonyms: CD163; M130; MM130; CD163 molecule; scavenger receptor cysteine-rich type 1 protein M130; hemoglobin scavenger receptor; macrophage-associated antigen
Gene ID: 9332
mRNA Refseq: NM_004244
Protein Refseq: NP_004235
MIM: 605545
UniProt ID: Q86VB7
Chromosome Location: 12p13.3
Pathway: Binding and Uptake of Ligands by Scavenger Receptors; Scavenging of Heme from Plasma
Function: protein binding; scavenger receptor activity

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