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Active Recombinant Human DSG3, Fc-tagged

Cat.No. : DSG3-38H
Product Overview : Recombinant Human DSG3 was expressed in Mouse NSO Cells.
  • Specification
  • Gene Information
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Description : Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.?
Source : Mammalian cells
Species : Human
Tag : Fc
Predicted N Terminal : Glu50
Form : Lyophilized from a 0.2 μm filtered solution in MES and NaCl.
Bio-activity : Measured by the ability of the immobilized protein to support the adhesion of Caki?2 human clear cell carcinoma epithelial cells.When 3 x 10^4 cells/well are added to rhDesmoglein-3 coated plates (10 μg/mL, 100 μL/well), approximately 45 - 65% will adhere after 90 minutes at 37° C.
Molecular Mass : Predicted Molecular Mass: 89.5 kDa (monomer)SDS-PAGE: 105-110 kDa, reducing conditions
Endotoxin : < 1.0 eu per 1 μg of the protein by the lal
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 °C as supplied.1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution : Reconstitute at 100 μg/mL in sterile PBS.
Gene Name : DSG3?desmoglein 3 [?Homo sapiens?(human) ]
Official Symbol : DSG3
Synonyms : DSG3; PVA; CDHF6; desmoglein 3; desmoglein-3; cadherin family member 6; pemphigus vulgaris antigen; 130-kD pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen
Gene ID : 1830
mRNA Refseq : NM_001944
Protein Refseq : NP_001935
MIM : 169615
UniProt ID : P32926
Chromosome Location : 18q12.1
Pathway : Apoptosis; Apoptotic cleavage of cell adhesion proteins; Apoptotic execution phase
Function : calcium ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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