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Recombinant Human major histocompatibility complex, class II, DO alpha, His-tagged

Cat.No. : HLA-DOA-232H
Product Overview : HLA-DOA, 26-217aa, Human, His tag, E.coli
  • Specification
  • Gene Information
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Description : HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. Recombinant human HLA-DAO protein, fused to His-tag at N-terminus, was expressed in E.coli.
Source : E.coli
Species : Human
Tag : His-tag
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol
Molecular Mass : 24.1 kDa (215aa)
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSTKADHMG SYGPAFYQSY GASGQFTHEF DEEQLFSVDL KKSEAVWRLP EFGDFARFDP QGGLAGIAAI KAHLDILVER SNRSRAINVP PRVTVLPKSR VELGQPNILI CIVDNIFPPV INITWLRNGQ TVTEGVAQTS FYSQPDHLFR KFHYLPFVPS AEDVYDCQVE HWGLDAPLLR HWELQVPIPP PDAME
Purity : >90% by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml (determined by Bradford assay)
Gene Name : HLA-DOA major histocompatibility complex, class II, DO alpha [ Homo sapiens ]
Official Symbol : HLA-DOA
Synonyms : HLA-DOA; major histocompatibility complex, class II, DO alpha; HLA DNA, HLA DZA; HLA class II histocompatibility antigen, DO alpha chain; HLA D0 alpha; HLA-D0-alpha; MHC DN-alpha; MHC DZ alpha; lymphocyte antigen; MHC class II antigen DOA; major histocompatibility complex, class II, DN alpha; HLADZ; HLA-DNA; HLA-DZA;
Gene ID : 3111
mRNA Refseq : NM_002119
Protein Refseq : NP_002110
MIM : 142930
UniProt ID : P06340
Chromosome Location : 6p21.3
Pathway : Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem;
Function : MHC class II receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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