Active Recombinant Canine NRG1
Cat.No. : | NRG1-178C |
Product Overview : | A DNA sequence encoding the canine NRG1 isoform alpha (XP_858147.1) extracellular domain (Ser19-Lys240) was expressed with five amino acids (DDDDK) at the C- terminus. |
- Specification
- Gene Information
- Related Products
Source : | Human Cells |
Species : | Canine |
Form : | Lyophilized from sterile PBS, pH7.4. |
Bio-activity : | Measured by its binding ability in a functional ELISA. Immobilized canine NRG1 at 10 μg/ml (100 μl/well) can bind human ErbB4-Fc, The EC50 of human ErbB4-Fc is 0.19-0.43 μg/ml. |
Molecular Mass : | The recombinant canine NRG1 comprises 228 amino acids and has a predicted molecular mass of 24.7 kDa. The apparent molecular mass of the protein is approximately 47 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
Protein length : | Ser19-Lys240 |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >95 % as determined by SDS-PAGE |
Stability : | Samples are stable for up to twelve months from date of receipt at -70℃ |
Storage : | Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | Hardcopy of COA with reconstitution instruction is sent along with the products. |
Gene Name : | NRG1 neuregulin 1 [ Canis lupus familiaris ] |
Official Symbol : | NRG1 |
Synonyms : | NRG1; neuregulin 1; pro-neuregulin-1, membrane-bound isoform; |
Gene ID : | 482861 |
Pathway : | ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem; |
Products Types
◆ Recombinant Protein | ||
NRG1-215H | Recombinant Human NRG1-β Protein | +Inquiry |
NRG1-7320H | Active Recombinant Human NRG1 protein(Ser2-Lys246), Fc-tagged | +Inquiry |
NRG1-141H | Active Recombinant Human NRG1 Protein (Ser177-Glu241), C-His tagged, Animal-free, Carrier-free | +Inquiry |
Nrg1-6199M | Recombinant Mouse Nrg1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NRG1-29H | Recombinant Human/Bovine/Porcine NRG1 Protein | +Inquiry |
◆ Lysates | ||
NRG1-1675HCL | Recombinant Human NRG1 cell lysate | +Inquiry |
NRG1-001CCL | Recombinant Canine NRG1 cell lysate | +Inquiry |
NRG1-836CCL | Recombinant Canine NRG1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionNRG1 is essential for neural development, influencing neuronal migration, myelination, and synapse formation. It also plays a role in synaptic plasticity, modulating neurotransmission and synaptic strength.
In the heart, NRG1 is involved in the regulation of cardiac development, including trabeculation. It also has protective effects on cardiac muscle cells and can influence heart repair mechanisms.
Dysregulation of NRG1 signaling has been implicated in several diseases, including schizophrenia, multiple sclerosis, and certain types of cancers. Genetic variations in the NRG1 gene have been associated with increased risk for some of these conditions.
Given the diverse roles of NRG1 in various physiological processes, it presents as a potential therapeutic target. For instance, recombinant NRG1 has been explored for heart failure treatment, and its modulation is being studied in the context of neural disorders and cancers.
Yes, there are multiple isoforms of NRG1, generated through alternative splicing. These isoforms can differ in their tissue distribution, receptor binding, and functional roles.
NRG1 primarily interacts with the ErbB family of tyrosine kinase receptors, especially ErbB3 and ErbB4. Upon binding, it activates downstream pathways such as the PI3K/Akt and MAPK pathways.
NRG1 is a versatile signaling molecule that plays crucial roles in the development and function of multiple organ systems, including the nervous system, heart, and breast.
Customer Reviews (3)
Write a reviewExcellent results, very consistent.
Worked great in assays.
Great product, very reliable.
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