Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

Recombinant Human ALPP, His-tagged

Cat.No. : ALPP-219H
Product Overview : A DNA sequence encoding human ALPP (AAH09647.1) (Ile23-Asp506) was expressed with a polyhistidine tag at the C-terminus.
  • Specification
  • Gene Information
  • Related Products
Source : Yeast
Species : Human
Tag : His
Form : Lyophilized from sterile PBS, pH7.4.
Molecular Mass : The recombinant human ALPP consists of 494 amino acids and predicts a molecular mass of 54.1 KDa. It migrates as an approximately 66 KDa band in SDS-PAGE under reducing conditions.
Protein length : Ile23-Asp506
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >80 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70℃
Storage : Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : Hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : ALPP alkaline phosphatase, placental [ Homo sapiens ]
Official Symbol : ALPP
Synonyms : ALPP; alkaline phosphatase, placental; alkaline phosphatase, placental (Regan isozyme); alkaline phosphatase, placental type; Regan isozyme; PLAP-1; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase Regan isozyme; ALP; PALP; PLAP; FLJ61142;
Gene ID : 250
mRNA Refseq : NM_001632
Protein Refseq : NP_001623
MIM : 171800
UniProt ID : P05187
Chromosome Location : 2q37.1
Pathway : Folate biosynthesis, organism-specific biosystem; Folate biosynthesis, conserved biosystem; Metabolic pathways, organism-specific biosystem;
Function : alkaline phosphatase activity; alkaline phosphatase activity; hydrolase activity; metal ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (10)

Ask a question
Can ALPP serve as a diagnostic biomarker or therapeutic target for specific diseases? 01/26/2022

ALPP may serve as a diagnostic biomarker for specific diseases, allowing for disease detection and monitoring, and its targeting could hold therapeutic potential in certain pathological conditions.

How does ALPP contribute to the metabolism and turnover of its substrate(s) in physiological and pathological conditions? 11/28/2021

ALPP participates in the metabolism and turnover of its substrate(s), including the hydrolysis of phosphoester bonds and the regulation of cellular phosphate homeostasis.

What are the downstream signaling pathways and molecular interactions regulated by ALPP in cellular functions? 12/22/2020

ALPP regulates downstream signaling pathways and molecular interactions involved in cellular processes like phosphate metabolism, intracellular signaling, and extracellular matrix remodeling.

What are the regulatory mechanisms controlling ALPP gene expression and enzyme activity? 12/15/2020

ALPP gene expression is regulated by transcription factors, epigenetic modifications, and signaling pathways involved in cellular homeostasis and disease processes.

What is the subcellular localization and trafficking of ALPP within cells? 11/09/2019

ALPP is localized to specific cellular compartments, such as the plasma membrane, endoplasmic reticulum, or lysosomes, and its trafficking may be regulated by sorting signals and intracellular transport machinery.

Can ALPP activity be modulated by specific factors or inhibitors, and how does this impact cellular processes? 07/17/2019

ALPP activity can be modulated by factors such as pH, calcium, and inhibitors, which can affect its catalytic efficiency and cellular functions.

How does ALPP deficiency or dysregulation contribute to the pathogenesis of diseases and disorders? 07/16/2019

ALPP deficiency or dysregulation is associated with various diseases, including metabolic disorders, bone diseases, and certain cancers, highlighting its pathological implications.

How can ALPP activity and function be manipulated to modulate cellular processes and disease outcomes? 09/12/2018

Manipulating ALPP activity and function could offer strategies to modulate cellular processes and disease outcomes, potentially leading to therapeutic interventions and improved patient outcomes.

How does ALPP expression and activity change during development, differentiation, and disease progression? 07/08/2018

ALPP expression and activity exhibit dynamic changes during development, cellular differentiation, and disease progression, reflecting its roles in different physiological and pathological contexts.

What is the expression pattern of ALPP in different tissues and cell types? 01/28/2017

ALPP shows a tissue-specific expression pattern, with higher levels in tissues such as liver, bone, and kidney, and lower levels in other organs.

Customer Reviews (3)

Write a review
Reviews
12/01/2020

    High-throughput screening compatibility.

    11/05/2018

      Consistent protein expression analysis.

      10/25/2017

        Precise protein quantification in ELISA.

        Ask a Question for All ALPP Products

        Required fields are marked with *

        My Review for All ALPP Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends