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Recombinant Rat Arpc1b, His-tagged

Cat.No. : Arpc1b-3103R
Product Overview : Actin-related protein 2/3 complex subunit 1B (Arpc1b)
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  • Gene Information
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Source : E. Coli or Yeast
Species : Rat
Tag : His
Form : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Protein length : 372
Purity : >90%
Notes : Small volumes of Arpc1b recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Storage Buffer : PBS pH 7.4, 50% glycerol
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : Arpc1b actin related protein 2/3 complex, subunit 1B [ Rattus norvegicus ]
Official Symbol : Arpc1b
Synonyms : ARPC1B; actin related protein 2/3 complex, subunit 1B; actin-related protein 2/3 complex subunit 1B; p41-ARC; arp2/3 complex 41 kDa subunit; Actin-related protein complex 1b;
Gene ID : 54227
mRNA Refseq : NM_019289
Protein Refseq : NP_062162
Pathway : B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem
Function : actin binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What diseases or disorders have been associated with dysregulation of the ARPC1B protein? 03/08/2023

Dysregulation of the ARPC1B protein has been implicated in various types of cancer, including breast cancer and colorectal cancer. Additionally, mutations or deletions in the ARPC1B gene have been linked to developmental disorders such as intellectual disability and abnormal brain development.

How does the ARPC1B protein contribute to cancer progression? 11/07/2022

The ARPC1B protein is involved in cancer progression by promoting cell motility, invasion, and metastasis. It functions within the Arp2/3 complex to facilitate the formation of actin-based protrusions that allow cancer cells to move and invade surrounding tissues.

Can modulation of the ARPC1B protein be considered as a potential therapeutic approach? 02/07/2021

Modulation of the ARPC1B protein or its associated Arp2/3 complex could be a potential therapeutic approach for diseases involving aberrant actin cytoskeleton dynamics or cellular motility. However, further research is necessary to fully understand the functional consequences of ARPC1B dysregulation and to develop targeted therapeutic strategies.

Are there any ARPC1B inhibitors or potential therapeutic targets? 06/29/2018

Currently, there are no specific inhibitors targeting the ARPC1B protein available for therapeutic use. However, as the Arp2/3 complex is an essential component of actin cytoskeleton regulation, inhibitors targeting the interaction between the complex and its activators may hold potential as anti-cancer agents.

What role does the ARPC1B protein play in brain development and intellectual disability? 02/08/2018

ARPC1B is expressed in the developing brain and is crucial for proper neuronal migration and cortical development. Mutations or deletions in the ARPC1B gene have been associated with intellectual disability and cortical malformations, which are thought to result from disrupted actin dynamics impairing the normal development and function of neural circuits.

Are there any known drugs or therapeutic approaches targeting ARPC1B? 09/17/2017

Currently, there are no specific drugs or therapeutic interventions targeting ARPC1B. However, as ARPC1B is involved in actin dynamics and cell migration, targeting other components of the actin cytoskeleton or signaling pathways that regulate actin polymerization may indirectly impact ARPC1B function and could be explored as potential therapeutic strategies.

Customer Reviews (3)

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Reviews
02/18/2023

    Their team of experts is highly knowledgeable, responsive, and dedicated to providing prompt solutions to any challenges I may face.

    06/25/2021

      By harnessing the power of the ARPC1B protein, I can harness its outstanding quality and tap into its potential to obtain dependable and meaningful findings.

      11/01/2018

        The ARPC1B protein is undoubtedly a superior choice, boasting extraordinary quality that guarantees it will fulfill all my experimental requirements.

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