Recombinant Human ADIPOR1, His-tagged, MBP tagged

• Cat.No.: ADIPOR1-3199H
• Product Overview: Adiponectin Receptor 1 (ADIPOR1)

Specification

• Description: This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14.
• Source: E. Coli
• Species: Human
• Tag: His,MBP
• Form: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Molecular Mass: 62.1kDa
• Protein length: 375
• Endotoxin: <1.0eu per 1ug (determined by the lal</1.0eu
• Purity: >95%
• Applications: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Notes: Small volumes of ADIPOR1 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: ADIPOR1 adiponectin receptor 1 [ Homo sapiens ]
• Official Symbol: ADIPOR1
• Synonyms: ADIPOR1; adiponectin receptor 1; adiponectin receptor protein 1; ACDCR1; PAQR1; progestin and adipoQ receptor family member I; CGI45; CGI-45; TESBP1A; FLJ25385; FLJ42464
• Gene ID: 51094
• mRNA Refseq: NM_015999
• Protein Refseq: NP_057083
• MIM: 607945
• UniProt ID: Q96A54
• Chromosome Location: 1q32.1
• Pathway: Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem
• Function: hormone binding; identical protein binding; protein heterodimerization activity; protein kinase binding; receptor activity

Reviews

12/12/2019

Top-notch customer service can significantly influence the outcome and accuracy of the study, and the prompt and diligent responses from the support team have resolved my issues efficiently.

09/11/2019

I deeply appreciate the exceptional technical support that the manufacturer provides, which has assisted in overcoming any obstacles during the experimental process.

03/05/2018

The protein was stable in Western Blotting experiments

11/16/2016

The ADIPOR1 protein antibody appears to be of exceptional quality, and I am confident that it will fulfill all my experimental requirements.

Q&As

Is there any correlation between ADIPOR1 expression and BMI?

Studies have shown that ADIPOR1 expression levels are generally lower in individuals with higher BMI and those with metabolic disorders, suggesting a potential link between ADIPOR1 expression and metabolic health. However, more research is needed to fully understand the relationship between ADIPOR1 and BMI.

Can genetic variations affect ADIPOR1 expression or function?

Yes, genetic variations in the ADIPOR1 gene have been identified that affect its expression and function. These variations may contribute to the development of metabolic disorders.

Are there any limitations in measuring ADIPOR1 expression levels?

Yes, measuring ADIPOR1 expression levels can be challenging due to variations in its expression across different tissues and cell types. Additionally, different assays may have varying levels of accuracy and precision.

How does ADIPOR1 affect liver function?

ADIPOR1 has been shown to play a role in regulating liver function and metabolism. Activation of ADIPOR1 can improve insulin sensitivity and glucose metabolism in the liver, while deficiency or dysfunction of ADIPOR1 may contribute to liver dysfunction and the development of nonalcoholic fatty liver disease (NAFLD).

Can ADIPOR1 polymorphisms affect response to treatment for metabolic or inflammatory diseases?

Yes, genetic polymorphisms of ADIPOR1 may affect response to treatment for metabolic or inflammatory diseases. For example, studies have shown that certain ADIPOR1 polymorphisms may be associated with differential response to antidiabetic medications, and may also affect response to anti-inflammatory therapies.

What role does ADIPOR1 play in aging?

ADIPOR1 is involved in regulating various processes related to aging, including glucose and lipid metabolism, inflammation, and oxidative stress. Studies have shown that ADIPOR1 expression and function may decline with age, and this may contribute to the development of age-related diseases such as type 2 diabetes, cardiovascular disease, and certain cancers.

How can ADIPOR1 be targeted for drug development?

ADIPOR1 can potentially be targeted for drug development by modulating its expression or function. Some potential strategies include developing ADIPOR1 agonists to activate the receptor and improve metabolic health, or ADIPOR1 antagonists to block its activity and inhibit cancer growth. However, more research is needed to fully understand the implications and potential therapeutic applications of ADIPOR1 targeting.

What diseases or conditions are associated with changes in ADIPOR1 expression or function?

Changes in ADIPOR1 expression or function have been implicated in the development of metabolic disorders, such as obesity, type 2 diabetes, and cardiovascular disease. Additionally, ADIPOR1 may play a role in the progression of certain cancers and neurodegenerative diseases.

Are there any limitations in measuring ADIPOR1 expression levels?

Yes, measuring ADIPOR1 expression levels can be challenging due to variations in its expression across different tissues and cell types. Additionally, different assays may have varying levels of accuracy and precision.

Can lifestyle changes affect ADIPOR1 expression or function?

Yes, lifestyle changes such as regular exercise and dietary modifications have been shown to increase ADIPOR1 expression and improve its function. This may contribute to the beneficial effects of these interventions on metabolic health.

Are there any genetic variants of ADIPOR1 associated with metabolic disorders?

Yes, several genetic variants of ADIPOR1 have been associated with various metabolic disorders, including type 2 diabetes, cardiovascular disease, and obesity. These variants may affect ADIPOR1 expression or function, leading to altered glucose and lipid metabolism.

How is ADIPOR1 expression measured?

ADIPOR1 expression can be measured using various techniques, including transcriptomics (analysis of RNA), proteomics (analysis of protein levels), and immunohistochemistry (visualization of ADIPOR1 in tissues).

Can ADIPOR1 expression be modulated by lifestyle interventions?

Yes, lifestyle interventions such as diet and exercise can modulate ADIPOR1 expression and function. For example, studies have shown that exercise can increase ADIPOR1 expression in muscle tissue, while dietary interventions can affect ADIPOR1 expression in adipose tissue.

Are there any natural compounds or dietary components that can activate ADIPOR1?

Several natural compounds and dietary components have been shown to activate ADIPOR1, including the polyphenol resveratrol, the flavonoid quercetin, and omega-3 fatty acids. These compounds may have therapeutic potential for improving metabolic health and reducing the risk of metabolic diseases.

Can ADIPOR1 be used as a biomarker or therapeutic target?

Yes, ADIPOR1 has been proposed as a potential biomarker for metabolic disorders, as changes in its expression or function may indicate disease risk or progression. Additionally, ADIPOR1 is being explored as a therapeutic target for the development of new treatments for metabolic disorders and other diseases.

Is ADIPOR1 involved in regulating inflammation?

Yes, ADIPOR1 has been shown to play a role in regulating inflammation. Studies have shown that ADIPOR1 activation can suppress inflammatory signaling pathways, while deficiency or dysfunction of ADIPOR1 may contribute to chronic inflammation and inflammation-related diseases.