"AXIN2" Related Products

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Recombinant Human AXIN2, His-tagged

Cat.No.: AXIN2-3796H
Product Overview: Axis Inhibition Protein 2 (AXIN2)
Description: The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Source: E. Coli
Species: Human
Tag: His
Form: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Molecular Mass: 32.7kDa
Protein length: 843
Endotoxin: <1.0eu per 1ug (determined by the lal</1.0eu
Purity: >95%
Applications: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
Notes: Small volumes of AXIN2 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name: AXIN2 axin 2 [ Homo sapiens ]
Official Symbol: AXIN2
Synonyms: AXIN2; axin 2; axin-2; axil; conductin; DKFZp781B0869; MGC126582; axin-like protein; axis inhibition protein 2; AXIL; MGC10366;
Gene ID: 8313
mRNA Refseq: NM_004655
Protein Refseq: NP_004646
MIM: 604025
UniProt ID: Q9Y2T1
Chromosome Location: 17q23-q24
Pathway: Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Canonical Wnt signaling pathway, organism-specific biosystem; Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Endometrial
Function: GTPase activator activity; I-SMAD binding; armadillo repeat domain binding; beta-catenin binding; beta-catenin binding; enzyme binding; protein kinase binding; signal transducer activity; ubiquitin protein ligase binding;

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