Active Recombinant Human TIMP3 protein, Fc-tagged

• Cat.No.: TIMP3-002H
• Product Overview: Recombinant Human TIMP3(Cys24-Pro211) fused with Fc region of human IgG1 at N-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: Cys24-Pro211
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to induce alkaline phosphatase production.
• Molecular Mass: The predicted molecular mass is 48 kDa, and the apparent molecular mass is approximately 55 kDa in SDS-PAGE under reducing conditions.
• Endotoxin: <0.06 EU/μg as determined by LAL test.
• Purity: >95%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade. Avoid freeze/thaw cycles.
• Reconstitution: Reconstitute with sterile water to a concentration of 1mg/ml. Add 1xPBS to the desired protein concentration.

Gene Information

• Gene Name: TIMP3 TIMP metallopeptidase inhibitor 3 [ Homo sapiens ]
• Official Symbol: TIMP3
• Synonyms: TIMP3; TIMP metallopeptidase inhibitor 3; SFD, tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); metalloproteinase inhibitor 3; TIMP-3; MIG-5 protein; protein MIG-5; tissue inhibitor of metalloproteinases 3; SFD; K222; K222TA2; HSMRK222
• Gene ID: 7078
• mRNA Refseq: NM_000362
• Protein Refseq: NP_000353
• MIM: 188826
• UniProt ID: P35625
• Chromosome Location: 22q12.3
• Pathway: Endochondral Ossification, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem
• Function: enzyme inhibitor activity; metal ion binding; metalloendopeptidase inhibitor activity; protein binding