Recombinant Human ICOS, MIgG2a Fc-tagged ICOS-1531H

Recombinant Human ICOS, MIgG2a Fc-tagged

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Recombinant Human ICOS, MIgG2a Fc-tagged

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Cat.No. : ICOS-1531H
Product Overview : The extracellular domain of human CD278 [ICOS] (NP_036224.1) (Glu21-Leu139) is fused to the N-terminus of the Fc region of mouse IgG2a.
Description : The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation
Source : CHO cells
Species : Human
Tag : MIgG2a Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its ability to inhibit human T cell proliferation induced by rhB7-H2/Fc Chimera in the presence of anti-CD3.
Molecular Mass : 40 KDa (monomer)
AA Sequence : Glu21-Leu139
Endotoxin : <0.06 eu/μg as determined by lal>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : ICOS inducible T-cell co-stimulator [ Homo sapiens ]
Official Symbol : ICOS
Synonyms : ICOS; inducible T-cell co-stimulator; inducible T-cell costimulator; activation inducible lymphocyte immunomediatory molecule; AILIM; CD278; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; CVID1; MGC39850;
Gene ID : 29851
mRNA Refseq : NM_012092
Protein Refseq : NP_036224
MIM : 604558
UniProt ID : Q9Y6W8
Chromosome Location : 2q33
Pathway : Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem;

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