Active Recombinant Human ICOS, MIgG2a Fc-tagged
Cat.No. : | ICOS-1531H |
Product Overview : | The extracellular domain of human CD278 [ICOS] (NP_036224.1) (Glu21-Leu139) is fused to the N-terminus of the Fc region of mouse IgG2a. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation |
Source : | CHO cells |
Species : | Human |
Tag : | MIgG2a Fc-tagged |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured by its ability to inhibit human T cell proliferation induced by rhB7-H2/Fc Chimera in the presence of anti-CD3. |
Molecular Mass : | 40 KDa (monomer) |
AA Sequence : | Glu21-Leu139 |
Endotoxin : | <0.06 eu/μg as determined by lal>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | ICOS inducible T-cell co-stimulator [ Homo sapiens ] |
Official Symbol : | ICOS |
Synonyms : | ICOS; inducible T-cell co-stimulator; inducible T-cell costimulator; activation inducible lymphocyte immunomediatory molecule; AILIM; CD278; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; CVID1; MGC39850; |
Gene ID : | 29851 |
mRNA Refseq : | NM_012092 |
Protein Refseq : | NP_036224 |
MIM : | 604558 |
UniProt ID : | Q9Y6W8 |
Chromosome Location : | 2q33 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; |
Products Types
◆ Recombinant Protein | ||
ICOS-1283R | Recombinant Rat ICOS protein(Met1-Leu142), hFc-tagged | +Inquiry |
ICOS-1248M | Acitve Recombinant Mouse ICOS protein(Met1-Gln135), His-tagged | +Inquiry |
ICOS-2636R | Recombinant Rat ICOS Protein, His (Fc)-Avi-tagged | +Inquiry |
ICOS-2008R | Recombinant Rhesus Macaque ICOS Protein, His (Fc)-Avi-tagged | +Inquiry |
ICOS-055H | Recombinant Human ICOS Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ICOS-1724MCL | Recombinant Mouse ICOS cell lysate | +Inquiry |
ICOS-2444HCL | Recombinant Human ICOS cell lysate | +Inquiry |
ICOS-1195RCL | Recombinant Rat ICOS cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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