Recombinant Human CYP2C19


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Recombinant Human CYP2C19

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Cat.No. : CYP2C19-542H
Product Overview : Recombinant Human CYP2C19 was expressed in Saccharomyces cerevisiae.
Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
Source : Saccharomyces cerevisiae
Species : Human
Form : 50 mM Tris (pH 7.4), 1 mM EDTA, 20% glycerol
Bio-activity : activity: ≥2 units/pmol enzymesecondary activity: ≥100 units/mg protein (Reductase activity)
Unit Definition : P450 Activity: One unit will oxidize 1 picomole of diclofenac per minute at pH 7.4 at 30 °C.Reductase Activity: One unit will reduce 1 nanomole of cytochrome C per minute in the presence of NADPH at pH 7.4 at 28 °C.
Storage : ?70°C
Concentration : ≤90 mg/mL (Protein)≥10 pmol/mg protein (P450)
Gene Name : CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 [ Homo sapiens (human) ]
Official Symbol : CYP2C19
Synonyms : CYP2C19; CPCJ; CYP2C; P450C2C; P450IIC19; cytochrome P450, family 2, subfamily C, polypeptide 19; cytochrome P450 2C19; CYPIIC17; CYPIIC19; cytochrome P450-11A; cytochrome P450-254C; cytochrome P-450 II C; microsomal monooxygenase; xenobiotic monooxygenase; mephenytoin 4-hydroxylase; mephenytoin 4"-hydroxylase; S-mephenytoin 4-hydroxylase; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19; NP_000760.1; EC; EC; EC
Gene ID : 1557
mRNA Refseq : NM_000769
Protein Refseq : NP_000760
MIM : 124020
UniProt ID : P33261
Chromosome Location : 10q24
Pathway : Arachidonic acid metabolism; CYP2E1 reactions; Linoleic acid metabolism
Function : (R)-limonene 6-monooxygenase activity; enzyme binding; iron ion binding

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