Active Recombinant Human TPR, GST-tagged
Cat.No. : | TPR-95H |
Product Overview : | Recombinant human fusion protein TPR (1-191)-TRKA (399-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
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Description : | TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family which is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TRKA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermoregulation via sweating in humans. As one of the thyroid TRK oncogenes, TRK-T1 is created by an intrachromosomal rearrangement that juxtaposes the 5" end of the TPR gene to the TRK tyrosine kinase domain and shows frequent activation of the TRK in human papillary thyroid carcinoma. |
Source : | Sf9 insect cells using baculovirus |
Species : | Human |
Tag : | GST |
Form : | 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Bio-activity : | 16 nmol/min/mg |
Molecular Mass : | ~96 kDa |
Purity : | >70% by densitometry |
Applications : | Kinase Assay |
Storage : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.05 ug/ul |
Gene Name : | TPR translocated promoter region, nuclear basket protein [ Homo sapiens ] |
Official Symbol : | TPR |
Synonyms : | TPR; translocated promoter region, nuclear basket protein; translocated promoter region (to activated MET oncogene); nucleoprotein TPR; tumor potentiating region; nuclear pore complex-associated protein TPR; |
Gene ID : | 7175 |
mRNA Refseq : | NM_003292 |
Protein Refseq : | NP_003283 |
MIM : | 189940 |
UniProt ID : | P12270 |
Chromosome Location : | 1q25 |
Pathway : | Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Disease, organism-specific biosystem; Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystem; Gene Expression, organism-specific biosystem; Glucose transport, organism-specific biosystem; HIV Infection, organism-specific biosystem; |
Function : | ATP binding; nucleotide binding; protein binding; serine-tRNA ligase activity; |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionPotentially, as TPR proteins play diverse roles in cellular processes, targeting them could lead to personalized therapeutic approaches for various diseases.
Some TPR proteins are involved in regulating cellular signaling pathways, influencing processes such as cell growth, differentiation, and apoptosis.
Some TPR proteins are involved in regulating mitochondrial function, which could have implications for diseases related to mitochondrial dysfunction.
TPR proteins are involved in the transport of proteins and other molecules within the cell, regulating the movement of cargo between different cellular compartments.
Research suggests that targeting TPR proteins involved in protein folding and transport could be a potential therapeutic approach for neurodegenerative diseases.
Customer Reviews (3)
Write a reviewIts consistent and accurate results, combined with its compatibility with various cutting-edge techniques, ensure that data collection and analysis are both reliable and meaningful.
The manufacturer's commitment to delivering a high-quality product further enhances its reputation and guarantees its suitability for a wide range of research applications.
The TPR protein's exceptional performance in ELISA and its successful application in protein electron microscopy structure analysis make it a highly reliable and recommended choice for researchers.
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