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Active Recombinant Human TPR, GST-tagged

Cat.No. : TPR-95H
Product Overview : Recombinant human fusion protein TPR (1-191)-TRKA (399-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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  • Gene Information
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Description : TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family which is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TRKA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermoregulation via sweating in humans. As one of the thyroid TRK oncogenes, TRK-T1 is created by an intrachromosomal rearrangement that juxtaposes the 5" end of the TPR gene to the TRK tyrosine kinase domain and shows frequent activation of the TRK in human papillary thyroid carcinoma.
Source : Sf9 insect cells using baculovirus
Species : Human
Tag : GST
Form : 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Bio-activity : 16 nmol/min/mg
Molecular Mass : ~96 kDa
Purity : >70% by densitometry
Applications : Kinase Assay
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.05 ug/ul
Gene Name : TPR translocated promoter region, nuclear basket protein [ Homo sapiens ]
Official Symbol : TPR
Synonyms : TPR; translocated promoter region, nuclear basket protein; translocated promoter region (to activated MET oncogene); nucleoprotein TPR; tumor potentiating region; nuclear pore complex-associated protein TPR;
Gene ID : 7175
mRNA Refseq : NM_003292
Protein Refseq : NP_003283
MIM : 189940
UniProt ID : P12270
Chromosome Location : 1q25
Pathway : Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Disease, organism-specific biosystem; Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystem; Gene Expression, organism-specific biosystem; Glucose transport, organism-specific biosystem; HIV Infection, organism-specific biosystem;
Function : ATP binding; nucleotide binding; protein binding; serine-tRNA ligase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can TPR protein-based therapies be used for personalized medicine? 11/01/2022

Potentially, as TPR proteins play diverse roles in cellular processes, targeting them could lead to personalized therapeutic approaches for various diseases.

How are TPR proteins involved in cellular signaling? 02/27/2021

Some TPR proteins are involved in regulating cellular signaling pathways, influencing processes such as cell growth, differentiation, and apoptosis.

What role do TPR proteins play in mitochondrial function? 11/20/2020

Some TPR proteins are involved in regulating mitochondrial function, which could have implications for diseases related to mitochondrial dysfunction.

How are TPR proteins involved in cellular transport? 08/26/2020

TPR proteins are involved in the transport of proteins and other molecules within the cell, regulating the movement of cargo between different cellular compartments.

Can TPR proteins be used as therapeutic targets for neurodegenerative diseases? 04/20/2020

Research suggests that targeting TPR proteins involved in protein folding and transport could be a potential therapeutic approach for neurodegenerative diseases.

Customer Reviews (3)

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Reviews
06/18/2021

    Its consistent and accurate results, combined with its compatibility with various cutting-edge techniques, ensure that data collection and analysis are both reliable and meaningful.

    04/24/2020

      The manufacturer's commitment to delivering a high-quality product further enhances its reputation and guarantees its suitability for a wide range of research applications.

      06/06/2016

        The TPR protein's exceptional performance in ELISA and its successful application in protein electron microscopy structure analysis make it a highly reliable and recommended choice for researchers.

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