Active Recombinant Human HDAC6, GST-tagged

• Cat.No.: HDAC6-405H
• Product Overview: Human HDAC6, GenBank Accession No. BC069243, full length with N-terminal GST-tag, MW= 159 kDa, expressed in baculovirus expression system.

Specification

• Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
• Source: Sf9 insect cells
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCl, pH 7.5, 500 mM NaCl, 50 mM KCl, 2 mM EDTA, 10% glycerol, and 2 mM DTT
• Bio-activity: ≥560 pmol/min/µg
• Molecular Mass: 159 kDa
• Purity: ≥85%
• Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Storage: >6 months at -80°C.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: HDAC6 histonedeacetylase 6 [ Homo sapiens ]
• Official Symbol: HDAC6
• Synonyms: HDAC6;histone deacetylase 6; HD6; JM21; FLJ16239; EC 3.5.1.98; protein phosphatase 1, regulatory subunit 90; KIAA0901;OTTHUMP00000032398; NP_006035.2; OTTHUMP00000197663
• Gene ID: 10013
• mRNA Refseq: NM_006044
• Protein Refseq: NP_006035
• MIM: 300272
• UniProt ID: Q9UBN7
• Chromosome Location: Xp11.23
• Pathway: Cell cycle; NOTCH1 Intracellular DomainRegulates Transcription; Signal Transduction; Signaling by NOTCH; Signalingby NOTCH1; Signaling events mediated by HDAC Class I; Signaling eventsmediated by HDAC Class II
• Function: Hsp90 protein binding; NAD-dependenthistone deacetylase activity (H3-K14 specific); NAD-dependent histonedeacetylase activity (H3-K9 specific); NAD-dependent histone deacetylaseactivity (H4-K16 specific); actin binding; alpha-tubulin binding; beta-cateninbinding; beta-tubulin binding; dynein complex binding; enzyme binding;histone deacetylase activity; histone deacetylase activity (H3-K16 specific);histone deacetylase binding; hydrolase activity; metal ion binding