Recombinant Human HDAC6, GST-tagged HDAC6-405H

Recombinant Human HDAC6, GST-tagged

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Recombinant Human HDAC6, GST-tagged

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Cat.No. : HDAC6-405H
Product Overview : Human HDAC6, GenBank Accession No. BC069243, full length with N-terminal GST-tag, MW= 159 kDa, expressed in baculovirus expression system.
Description : Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
Source : Sf9 insect cells
Species : Human
Tag : GST
Form : 50 mM Tris-HCl, pH 7.5, 500 mM NaCl, 50 mM KCl, 2 mM EDTA, 10% glycerol, and 2 mM DTT
Bio-activity : ≥560 pmol/min/µg
Molecular Mass : 159 kDa
Purity : ≥85%
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage : >6 months at -80°C.
Warning : Avoid freeze/thaw cycles.
Gene Name : HDAC6 histonedeacetylase 6 [ Homo sapiens ]
Official Symbol : HDAC6
Synonyms : HDAC6;histone deacetylase 6; HD6; JM21; FLJ16239; EC 3.5.1.98; protein phosphatase 1, regulatory subunit 90; KIAA0901;OTTHUMP00000032398; NP_006035.2; OTTHUMP00000197663
Gene ID : 10013
mRNA Refseq : NM_006044
Protein Refseq : NP_006035
MIM : 300272
UniProt ID : Q9UBN7
Chromosome Location : Xp11.23
Pathway : Cell cycle; NOTCH1 Intracellular DomainRegulates Transcription; Signal Transduction; Signaling by NOTCH; Signalingby NOTCH1; Signaling events mediated by HDAC Class I; Signaling eventsmediated by HDAC Class II;
Function : Hsp90 protein binding; NAD-dependenthistone deacetylase activity (H3-K14 specific); NAD-dependent histonedeacetylase activity (H3-K9 specific); NAD-dependent histone deacetylaseactivity (H4-K16 specific); actin binding; alpha-tubulin binding; beta-cateninbinding; beta-tubulin binding; dynein complex binding; enzyme binding;histone deacetylase activity; histone deacetylase activity (H3-K16 specific);histone deacetylase binding; hydrolase activity; metal ion binding

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