Recombinant Human Fibroblast Growth Factor Receptor 1, Fc-tagged FGFR1-01H

Recombinant Human Fibroblast Growth Factor Receptor 1, Fc-tagged

PRODUCTS

Home / Products / Recombinant Proteins / Recombinant Human Fibroblast Growth Factor Receptor 1, Fc-tagged

Recombinant Human Fibroblast Growth Factor Receptor 1, Fc-tagged

FGFR1 Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat. No. : FGFR1-01H
Product Overview : Recombinant Human Soluble FGFR-1a (IIIc) Fc Chimera fused with Xa cleavage site with the Fc part of human IgG1 produced in baculovirus is a heterodimeric, glycosylated, Polypeptide chain and having a molecular mass of 190 kDa. The FGFR1 is purified by proprietary chromatographic techniques.
Description : Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally realted proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family if type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGFR-1to -4 are known. Multiple forms of FGFR-1 to -3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the ß isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). A IIIa isoform which is a secreted FGF binding protein containing only the N-terminal half of the IgIII domain plus some intron sequences has also been reported for FGFR-1. Mutations in FGFR-1 to -3 have been found in patients with birth defects involving craniosynostosis.
Source : Insect Cells
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Purity : Greater than 90.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : CD331 was lyophilized from a concentrated (1 mg/ml) sterile solution containing no additives.
Solubility : It is recommended to reconstitute the lyophilized bFGF-R in sterile PBS not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Biological Activity : Determined by its ability to inhibit human FGF acidic-dependent proliferation on R1 cells. The ED50 for this effect is typically at 15.0-30.0 ng/ml.
Storage : Lyophilized FGFR1A although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution FGFR1 should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
PDB rendering based on 1agw. :

Gene Name : FGFR1 fibroblast growth factor receptor 1 [ Homo sapiens ]
Synonyms : FGFR1; fibroblast growth factor receptor 1; CEK; FLG; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; HBGFR; N-SAM; FLJ99988; fms-related tyrosine kinase 2; H2; H3; H4; H5; N-SAM; CD331; Pfeiffer syndrome; FGFR-1; bFGF-R; EC 2.7.10.1; Fms-like tyrosine kinase 2; c-fgr; CD_antigen; OTTHUMP00000190881; soluble FGFR1 variant 1; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1; OTTHUMP00000190874; OTTHUMP00000190878; OTTHUMP00000190879; c-fgr; soluble FGFR1 variant 2
Gene ID : 2260
mRNA Refseq : NM_015850
Protein Refseq : NP_056934
MIM : 136350
UniProt ID : P11362
Chromosome Location : 8p11.2-p11.1
Pathway : MAPK signaling pathway; MAPK signaling pathway; Melanoma; Pathways in cancer; Prostate cancer; Regulation of actin cytoskeleton; Axon guidance; Signaling by FGFR
Function : ATP binding; fibroblast growth factor receptor activity; fibroblast growth factor receptor activity; heparin binding; nucleotide binding; protein binding; receptor activity; transferase activity

Online Inquiry


  • Note: There will be extra charge for optional service!
  • Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2007 – 2020 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy