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Recombinant Human TRAF6 293 Cell Lysate

Cat.No. : TRAF6-818HCL
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  • Gene Information
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Description : Antigen standard for TNF receptor-associated factor 6 (TRAF6), transcript variant 1 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
Source : HEK 293 cells
Species : Human
Components : This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Size : 0.1 mg
Storage Instruction : Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Applications : ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Gene Name : TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase [ Homo sapiens ]
Official Symbol : TRAF6
Synonyms : TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase; TNF receptor associated factor 6; TNF receptor-associated factor 6; RNF85; RING finger protein 85; interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6; MGC:3310;
Gene ID : 7189
mRNA Refseq : NM_145803
Protein Refseq : ?NP_665802
MIM : 602355
UniProt ID : Q9Y4K3
Chromosome Location : 11p12
Pathway : Activated TLR4 signalling, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; BCR signaling pathway, organism-specific biosystem; CD40/CD40L signaling, organism-specific biosystem; Canonical NF-kappaB pathway, organism-specific biosystem; Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What role does TRAF6 protein play in cancer development and progression? 01/28/2022

TRAF6 has been implicated in promoting the survival, proliferation, and metastasis of cancer cells, and its overexpression has been linked to poor prognosis in various types of cancer.

Are there any potential therapeutic strategies targeting TRAF6 protein in clinical practice? 12/01/2020

Research is underway to develop small molecule inhibitors and antibodies targeting TRAF6 for the treatment of inflammatory and autoimmune diseases, as well as cancer.

What are the biomarkers associated with TRAF6 protein expression in clinical diagnostics? 07/17/2019

Elevated levels of TRAF6 expression have been detected in the blood and tissue samples of patients with autoimmune diseases and certain types of cancer, making it a potential biomarker for disease diagnosis and prognosis.

How does TRAF6 protein interact with other signaling molecules in the cell? 01/05/2018

TRAF6 interacts with various receptors and adaptor proteins to activate downstream signaling pathways, including the NF-κB, MAPK, and JNK pathways, which are critical for immune and inflammatory responses.

How does TRAF6 protein contribute to bone metabolism? 12/25/2017

TRAF6 is involved in the regulation of osteoclast differentiation and bone resorption, making it a potential target for the treatment of bone-related diseases such as osteoporosis.

Customer Reviews (3)

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Reviews
04/26/2023

    The TRAF6 protein comes highly recommended due to its exceptional performance in ELISA assays.

    10/06/2017

      I am genuinely excited to embark on this scientific journey, empowered by the superior TRAF6 protein and the manufacturer's unwavering commitment to ensuring my success.

      05/10/2017

        The TRAF6 protein's superior performance in ELISA paves the way for robust and precise data analysis, providing invaluable insights into various biological processes.

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