"CSK" Related Products


Recombinant Human c-src tyrosine kinase

Cat. No.: CSK-27H
Product Overview: Recombinant Human CSRC produced inSf9 cellsis a glycosylated, polypeptide chain having a molecular mass of 60 KD. CSRC is purified by proprietary chromatographic techniques.
Description: SRC family kinases are involved in transducing growth factor signals for cellular differentiation and proliferation in a variety of cell types. The activity of all Src family kinases (SFKs) is controlled by phosphorylation at their C-terminal 527-tyrosine residue by C-terminal SRC kinase, CSK. The C-terminal SRC kinase (CSK) family of protein tyrosine kinases contains two members: CSK and CSK homologous kinase (CHK). Both phosphorylate and inactivate SRC family kinases. C-terminal SRC kinase (CSK) contains a catalytic domain and a regulatory region, consisting of an SH3 and an SH2 domain.
Source: Sf9 Insect Cells.
Physical Appearance: Sterile Filtered clear solution.
Purity: Greater than 95% as determined by SDS-PAGE.
Formulation: C-SRC is supplied at a concentration of 0.29mg/ml in 50mM Tris, pH 7.6, 0.15 M NaCl, 0.27M sucrose, 1mM DTT, 0.1mM EGTA, 0.2mM PMSF, 1mM benzamidine, 5mM NaF, 10mM β-glycerol phosphate, 0.1mM sodium vanadate and 0.03% Brij-35.
Biological Activity: 750 units/mg. One unit of C-SRC activity is equal to 1 nmol of phosphate transferred to a peptide corresponding to p34cdc2 (6-20) per minute at 30°C with a final ATP concentration of 100 µM. Recombinant human active C-SRC also phosphorylates STAT, p34cdc2, gastrin, and cortactin.Please note: Kinase activity may vary depending on the substrate and reaction conditions.
Storage: Store at 4°C if entire vial will be used within 1-2 weeks. Store frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Gene Name: CSK c-src tyrosine kinase [ Homo sapiens ]
Synonyms: CSK; c-src tyrosine kinase; MGC117393; EC; C-SRC kinase ; Protein-tyrosine kinase CYL
Gene ID: 1445
mRNA Refseq: NM_001127190
Protein Refseq: NP_001120662
MIM: 124095
UniProt ID: P41240
Chromosome Location: 15q23-q25
Pathway: Chemokine signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Neurotrophin signaling pathway; Regulation of actin cytoskeleton
Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein C-terminus binding; transferase activity

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.