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Recombinant Human PAK4 293 Cell Lysate

Cat.No. : PAK4-3456HCL
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  • Gene Information
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Description : Antigen standard for p21 protein (Cdc42/Rac)-activated kinase 4 (PAK4), transcript variant 1 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
Source : HEK 293 cells
Species : Human
Components : This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Size : 0.1 mg
Storage Instruction : Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Applications : ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Gene Name : PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 [ Homo sapiens ]
Official Symbol : PAK4
Synonyms : PAK4; p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A) activated kinase 4; serine/threonine-protein kinase PAK 4; PAK-4; p21-activated kinase 4; p21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs;
Gene ID : 10298
mRNA Refseq : NM_005884
Protein Refseq : NP_005875
MIM : 605451
UniProt ID : O96013
Chromosome Location : 19p11-q11
Pathway : Activation of Rac, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; CDC42 signaling events, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem;
Function : ATP binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any FDA-approved drugs targeting PAK4? 12/19/2021

As of my knowledge cutoff date in January 2022, there were no FDA-approved drugs specifically targeting PAK4.

Are there any diagnostic tests based on PAK4 for cancer screening? 05/19/2021

PAK4 is not commonly used as a specific diagnostic marker for cancer screening. Other markers, like PSA for prostate cancer or mammography for breast cancer, are more common.

What are the current clinical trials involving PAK4 inhibitors? 06/26/2020

Clinical trials involving PAK4 inhibitors may vary over time. To find the latest information, you should consult clinical trial databases or healthcare professionals.

What are the challenges in developing PAK4 inhibitors for clinical use? 02/08/2020

Selectivity and potential side effects are challenges in developing PAK4 inhibitors, which need to be carefully addressed in clinical trials.

How is PAK4-related research contributing to personalized medicine? 05/14/2019

PAK4-related research may help identify specific patient populations that could benefit from PAK4-targeted therapies, contributing to personalized treatment approaches.

Customer Reviews (3)

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Reviews
11/16/2021

    The prompt and knowledgeable assistance they offer has greatly enhanced my confidence in using the PAK4 protein.

    03/01/2020

      I am highly satisfied with the performance and support associated with this protein, as it has proven to be an essential tool in advancing my scientific investigations.

      05/18/2016

        Its purity and reliability have provided consistent and reliable results in my research.

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