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Recombinant Human MYD88 293 Cell Lysate

Cat.No. : MYD88-4034HCL
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  • Gene Information
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Description : Antigen standard for myeloid differentiation primary response gene (88) (MYD88) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
Source : HEK 293 cells
Species : Human
Components : This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Size : 0.1 mg
Storage Instruction : Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Applications : ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Gene Name : MYD88 myeloid differentiation primary response gene (88) [ Homo sapiens ]
Official Symbol : MYD88
Synonyms : MYD88; myeloid differentiation primary response gene (88); myeloid differentiation primary response protein MyD88; MYD88D;
Gene ID : 4615
mRNA Refseq : NM_001172566
Protein Refseq : NP_001166037
MIM : 602170
UniProt ID : Q99836
Chromosome Location : 3p22
Pathway : Activated TLR4 signalling, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem;
Function : TIR domain binding; Toll binding; death receptor binding; identical protein binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does MYD88 contribute to the formation of the Myddosome complex in TLR signaling? 12/13/2021

MYD88 recruits IRAK kinases to form the Myddosome complex, initiating a signaling cascade that culminates in the activation of NF-κB and pro-inflammatory gene expression.

How is the expression of the MYD88 gene regulated at the molecular level? 06/26/2020

MYD88 expression is tightly regulated at the transcriptional level by various factors, including transcription factors and epigenetic modifications.

Explain the role of MYD88 in the recognition of microbial components by the immune system. 03/09/2019

MYD88 is a key mediator in the recognition of microbial components by TLRs, initiating signaling cascades that trigger immune responses against pathogens.

What are the downstream signaling pathways activated by MYD88, and how do they influence immune responses? 10/26/2018

MYD88 activates NF-κB and MAPK signaling pathways, leading to the production of pro-inflammatory cytokines and interferons that orchestrate immune responses.

Explain the role of MYD88 in adaptive immunity and its crosstalk with T and B cell responses. 05/01/2018

MYD88 plays a role in shaping adaptive immune responses by influencing the activation and differentiation of T and B cells, promoting an effective immune defense.

Customer Reviews (3)

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Reviews
02/26/2022

    Top-tier service—customer support's expertise ensured the perfect protein fit.

    01/09/2019

      Dependable quality and service—this recombined protein is a lab favorite.

      05/23/2018

        Rapid delivery, precise results—this product is a lab essential.

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