Recombinant Human MALT1 293 Cell Lysate

• Cat.No.: MALT1-4527HCL

Specification

• Description: Antigen standard for mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1), transcript variant 1 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
• Source: HEK 293 cells
• Species: Human
• Components: This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
• Size: 0.1 mg
• Storage Instruction: Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
• Applications: ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.

Gene Information

• Gene Name: MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 [ Homo sapiens ]
• Official Symbol: MALT1
• Synonyms: MALT1; mucosa associated lymphoid tissue lymphoma translocation gene 1; MLT; mucosa-associated lymphoid tissue lymphoma translocation protein 1; paracaspase; caspase-like protein; MALT associated translocation; MALT lymphoma-associated translocation; MALT-lymphoma associated translocation; MLT1; DKFZp434L132
• Gene ID: 10892
• mRNA Refseq: NM_006785
• Protein Refseq: NP_006776
• MIM: 604860
• UniProt ID: Q9UDY8
• Chromosome Location: 18q21
• Pathway: Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; BCR signaling pathway, organism-specific biosystem; Canonical NF-kappaB pathway, organism-specific biosystem; Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem
• Function: cysteine-type endopeptidase activity; contributes_to kinase activator activity; peptidase activity; protein binding; protein self-association; signal transducer activity; ubiquitin-protein ligase activity

Reviews

06/26/2022

From recombinant protein production to modification or labeling services, the company is committed to assisting researchers in obtaining the MALT1 protein in the format and specifications required for their particular studies.

08/19/2020

the manufacturer understands the importance of customization and can offer tailored solutions to meet specific research needs.

03/20/2020

the MALT1 protein's exceptional qualities, combined with the manufacturer's comprehensive technical support, make it an ideal choice for researchers seeking reliable experimental materials and reliable assistance in their scientific endeavors.

Q&As

Can MALT1 protein play a role in regulating immune responses in transplant patients?

MALT1 inhibitors are being investigated to prevent graft rejection and reduce the need for immunosuppressive drugs in transplant recipients.

Are there any genetic mutations or polymorphisms related to MALT1 protein that impact patient health?

Some genetic variations in MALT1 may influence susceptibility to certain diseases, including autoimmune conditions.

Are there any clinical applications for MALT1 protein in cancer research?

Yes, MALT1 is implicated in lymphoma and other hematological malignancies, making it a potential therapeutic target.

Can MALT1 protein be targeted for cancer treatment?

Yes, researchers are exploring MALT1 inhibitors as potential cancer therapeutics to block its activity in lymphomas.

How does MALT1 protein contribute to lymphocyte activation and proliferation?

MALT1 is involved in the activation of T and B cells, which are essential for the adaptive immune response.