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Recombinant Human CASP6 293 Cell Lysate

Cat.No. : CASP6-7834HCL
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Description : Antigen standard for caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
Source : HEK 293 cells
Species : Human
Components : This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Size : 0.1 mg
Storage Instruction : Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Applications : ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Gene Name : CASP6 caspase 6, apoptosis-related cysteine peptidase [ Homo sapiens ]
Official Symbol : CASP6
Synonyms : CASP6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis related cysteine protease; caspase-6; MCH2; apoptotic protease MCH-2; caspase 6, apoptosis-related cysteine protease;
Gene ID : 839
mRNA Refseq : NM_001226
Protein Refseq : NP_001217
MIM : 601532
UniProt ID : P55212
Chromosome Location : 4q25
Pathway : Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis Modulation by HSP70, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem;
Function : cysteine-type endopeptidase activity; cysteine-type peptidase activity; peptidase activity; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any potential therapeutic applications of targeting CASP6 in Alzheimer's disease? 09/27/2021

Targeting CASP6 activity may offer a potential therapeutic strategy for slowing down the progression of Alzheimer's disease.

Can targeting CASP6 protein have applications beyond neurodegenerative diseases? 11/16/2019

There is potential for CASP6 to be targeted in other diseases involving aberrant cell death pathways, such as certain types of cancer and autoimmune diseases.

Are there any specific drugs that target CASP6 protein? 08/28/2019

Several research groups are working on developing small molecule inhibitors and other drugs that specifically target CASP6 for therapeutic purposes.

Are there any potential side effects of targeting CASP6 for therapeutic purposes? 04/25/2017

As with any targeted therapy, potential side effects and off-target effects of CASP6 inhibition or modulation need to be carefully evaluated in clinical trials.

What other diseases are being studied in relation to CASP6 protein? 04/02/2016

CASP6 is also being investigated in the context of other neurodegenerative disorders such as Parkinson's disease and amyotrophic lateral sclerosis (ALS).

Customer Reviews (3)

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Reviews
12/24/2022

    Its remarkable performance in ELISA, protein electron microscopy structure analysis, and Western Blotting sets it apart as a top recommendation.

    12/13/2018

      The CASP6 protein has proven invaluable in protein electron microscopy structure analysis, allowing for detailed investigations and providing critical insights.

      02/12/2018

        Whether it's protein quantification, structural analysis, or Western Blotting, the CASP6 protein has consistently delivered exceptional results, earning my highest recommendation.

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