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Recombinant Human AKR1A1 293 Cell Lysate

Cat.No. : AKR1A1-8932HCL
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Description : Antigen standard for aldo-keto reductase family 1, member A1 (aldehyde reductase) (AKR1A1), transcript variant 2 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
Source : HEK 293 cells
Species : Human
Components : This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Size : 0.1 mg
Storage Instruction : Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Applications : ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Gene Name : AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) [ Homo sapiens ]
Official Symbol : AKR1A1
Synonyms : AKR1A1; aldo-keto reductase family 1, member A1 (aldehyde reductase); alcohol dehydrogenase [NADP(+)]; ALR; DD3; dihydrodiol dehydrogenase 3; aldehyde reductase; alcohol dehydrogenase; aldo-keto reductase family 1 member A1; ARM; ALDR1; MGC1380; MGC12529;
Gene ID : 10327
mRNA Refseq : NM_153326
Protein Refseq : NP_697021
MIM : 103830
UniProt ID : P14550
Chromosome Location : 1p33-p32
Pathway : Glycerolipid metabolism, organism-specific biosystem; Glycerolipid metabolism, conserved biosystem; Glycolysis / Gluconeogenesis, organism-specific biosystem; Glycolysis / Gluconeogenesis, conserved biosystem; Metabolic pathways, organism-specific biosystem; tryptophan degradation X (mammalian, via tryptamine), organism-specific biosystem;
Function : L-glucuronate reductase activity; alditol:NADP+ 1-oxidoreductase activity; electron carrier activity; oxidoreductase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (12)

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What diseases is AKR1A1 protein associated with? 04/08/2023

AKR1A1 protein is involved in many diseases, such as metabolic diseases, tumors, autoimmune diseases, etc.

Can you briefly describe the structure and function of AKR1A1 protein? 03/20/2022

The AKR1A1 protein is a REDOX enzyme capable of reducing and oxidizing a variety of compounds, such as toxins and drugs, to maintain the stability of the internal and external environment of the cell.

In what medical fields are inhibitors of AKR1A1 protein applied? 11/30/2021

AKR1A1 protein inhibitors have been used in the treatment of leukemia, AIDS, diabetes and other diseases.

In what parts or cells of the human body does AKR1A1 protein primarily act? 07/25/2021

This protein mainly plays a role in liver, lung, eye, intestine, kidney, prostate, stomach and other parts and a variety of cells, such as germ cells, neurons, alveolar epithelial cells, liver cells and so on.

What metabolic processes does AKR1A1 protein play an important role in? 05/07/2021

AKR1A1 protein plays an important role in various metabolic processes, such as the metabolism of vitamin A and various hormones.

AKR1A1 protein is closely related to the metabolism of which drugs? 02/28/2021

AKR1A1 protein is associated with the metabolism and toxicity of many drugs, such as phenol, pyruvate, acetaminophen, etc.

Which treatments are associated with AKR1A1 protein expression levels? 12/21/2020

The expression level of AKR1A1 protein is related to the therapeutic effect of certain drugs on diseases.

The high expression of AKR1A1 protein is related to the occurrence and development of which diseases? 12/06/2020

The high expression of AKR1A1 protein is associated with the occurrence and development of many diseases, such as tumors, metabolic diseases, and autoimmune diseases.

Do mutations in AKR1A1 protein cause disease? 09/12/2020

AKR1A1 protein gene mutation has a certain relationship with the occurrence of some diseases, such as tumors, metabolic diseases and so on.

Which cell growth and apoptosis processes does AKR1A1 protein play a role in? 06/25/2019

AKR1A1 protein plays a role in tumor cell growth and apoptosis.

Have any studies found any difference in the expression level of AKR1A1 protein in liver cancer and other tumors? 06/01/2019

The expression level of AKR1A1 in liver cancer cells and other tumor cells is different from that in normal cells and is closely related to the proliferation and metastasis of tumor cells.

How does AKR1A1 function differently from other proteins? 04/11/2019

AKR1A1 protein plays a more prominent role in metabolic reduction than other proteins, and its deposition and expression levels are closely related to the occurrence and development of a variety of diseases.

Customer Reviews (4)

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Reviews
05/20/2023

    Have high sensitivity and specificity in biosensor preparation.

    05/13/2022

      It promoted cell growth and proliferation.

      04/29/2021

        Good selectivity for specific disease-related targets.

        05/19/2020

          Iinhibitory or killing effect on specific pathogens.

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