Recombinant Human ALAS2 cell lysate

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Recombinant Human ALAS2 cell lysate

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Cat.No. : ALAS2-55HCL
Description : The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.
Species : Human
Size : 100 ug
Recommended Usage : Use it directly for immuno-precipitation, or heat lysate with SDS gel loading buffer to 95°C for 5 minutes followed by rapid cooling for western blot application. If dissociating conditions are required, add reducing agent prior to heating.
Storage Buffer : In modified RIPA Lysis Buffer.
Applications : Western Blot;Immunoprecipitation;
Gene Name : ALAS2 aminolevulinate, delta-, synthase 2 [ Homo sapiens ]
Official Symbol : ALAS2
Synonyms : ALAS2; aminolevulinate, delta-, synthase 2; aminolevulinate, delta , synthase 2 (sideroblastic/hypochromic anemia) , ASB; 5-aminolevulinate synthase, erythroid-specific, mitochondrial; sideroblastic/hypochromic anemia; delta-ALA synthase 2; delta-ALA synthetase; 5-aminolevulinic acid synthase 2; delta-aminolevulinate synthase 2; ASB; ANH1; XLSA; ALASE; XLDPP; XLEPP; ALAS-E; FLJ93603;
Gene ID : 212
mRNA Refseq : NM_000032
Protein Refseq : NP_000023
MIM : 301300
UniProt ID : P22557
Chromosome Location : Xp11.21
Pathway : Glycine, serine and threonine metabolism, organism-specific biosystem; Glycine, serine and threonine metabolism, conserved biosystem; Heme Biosynthesis, organism-specific biosystem; Heme biosynthesis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of porphyrins, organism-specific biosystem;
Function : 5-aminolevulinate synthase activity; 5-aminolevulinate synthase activity; coenzyme binding; glycine binding; protein binding; pyridoxal phosphate binding; transferase activity, transferring acyl groups; transferase activity, transferring nitrogenous groups;

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