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Recombinant Human MMP7

Cat.No. : MMP7-40H
Product Overview : Recombinant Human Matrix Metalloproteinase-7 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing having a molecular mass of 19.13 kDa. The MMP-7 is purified by proprietary chromatographic techniques.
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Cat. No. : MMP7-40H
Description : Matrix metalloproteinase-7 (MMP-7) also known as matrilysin and PUMP (EC 3.4.24.23) cleaves a number of substrates including collagen types IV and X, elastin, fibronectin, gelatin, laminin and proteoglycans. MMP-7 is closely related to the stromelysin family members but is encoded by a different gene. MMP-7 is the smallest of all the MMPs consisting of a pro-peptide domain and a catalytic domain. It lacks the hemopexin-like domain common to other members of the MMPs. MMP-7 is secreted as a 28 kDa proenzyme and can be activated in vitro by organomercurials and trypsin and in vivo by MMP-3 to a 18 kDa active MMP-7 enzyme. Once activated, MMP-7 can activate pro-MMP-1 and pro-MMP-9 but not pro-MMP-2. MMP-7 is widely expressed having been reported in elevated levels in cycling endometrium as well as in colorectal cancers and adenomas, hepatocellular carcinomas, rectal carcinomas, and approximately 50% of gliomas.
Source : Escherichia Coli.
Physical Appearance : Sterile clear liquid solution.
Purity : Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : The protein (0.83 mg/ml) contains the following additives 10 mM HEPES (pH 7.4), 5 mM CaCl2 and 150 mM NaCl.
Biological Activity : The specific activity was found to be 3100 IU/mg.
Unit Definition : One unit is defined as the digestion of 1 µg Azocoll/min at 37°C.
Recommended Use : Western Blotting (1:1K-5K for neat serum and 1-10 ug/ml for affinity pure antibody using ECL technique). ELISA: Control peptide can be used to coat ELISA plates at 1 ug/ml and detected with antibodies (1:10-50K for neat serum and 0.5-1 ug/ml for affinity pure). Histochemistry & Immunofluorescence: Not tested.
Stability : Matrilysin although stable at 4°C for 3 weeks, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Gene Name : MMP7 matrix metallopeptidase 7 (matrilysin, uterine) [ Homo sapiens ]
Synonyms : MMP7; matrix metallopeptidase 7 (matrilysin, uterine); MMP-7; MPSL1; PUMP-1; matrix metalloproteinase 7; matrin; uterine matrilysin; EC 3.4.24.23; Matrix metalloproteinase-7; Pump-1 protease; Uterine metalloproteinase; PUMP1; Matrin
Gene ID : 4316
mRNA Refseq : NM_002423
Protein Refseq : NP_002414
MIM : 178990
UniProt ID : P09237
Chromosome Location : 11q21-q22
Pathway : Wnt signaling pathway
Function : calcium ion binding; metalloendopeptidase activity; peptidase activity; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What clinical conditions are associated with MMP7 overexpression? 01/31/2023

MMP7 overexpression has been linked to various diseases, including cancer, inflammatory disorders, and tissue fibrosis.

In what ways does MMP7 contribute to inflammatory processes? 05/20/2020

MMP7 is involved in the degradation of extracellular matrix components during inflammation, influencing tissue damage and repair processes.

How can MMP7 be targeted for therapeutic interventions? 01/20/2020

Developing specific inhibitors that target MMP7 activity is a potential approach for therapeutic interventions, particularly in diseases where MMP7 plays a detrimental role.

Are there any inhibitors developed for MMP7? 10/19/2017

Several MMP inhibitors have been investigated, and some show promise in controlling MMP7 activity. However, their clinical use is still under research.

How is MMP7 involved in cancer progression? 01/13/2017

MMP7 facilitates cancer cell invasion and metastasis by degrading the extracellular matrix, allowing cancer cells to invade surrounding tissues and spread to distant organs.

Can MMP7 be used as a biomarker for cancer diagnosis? 01/09/2016

Yes, elevated levels of MMP7 have been observed in the serum or tissues of cancer patients, making it a potential biomarker for certain types of cancer.

Customer Reviews (3)

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Reviews
05/01/2023

    This includes rigorous quality control measures to ensure the consistency and purity of the protein, thereby reducing variability in the experimental outcomes.

    05/13/2022

      by utilizing MMP7 protein in trials and collaborating with a supportive manufacturer, researchers can gain access to a versatile tool that can aid in their understanding of angiogenesis and vascular biology.

      05/26/2018

        With expert assistance and reliable product quality, researchers can conduct their experiments with confidence, enabling them to contribute to advancements in the field and potentially improve future therapeutic interventions.

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