Recombinant Human CREBL2 cell lysate

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Recombinant Human CREBL2 cell lysate

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Cat.No. : CREBL2-398HCL
Description : cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene.
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : CREBL2 cAMP responsive element binding protein-like 2 [ Homo sapiens ]
Official Symbol : CREBL2
Synonyms : CREBL2; cAMP responsive element binding protein-like 2; cAMP-responsive element-binding protein-like 2; MHBs-binding protein 1; MGC117311; MGC138362;
Gene ID : 1389
mRNA Refseq : NM_001310
Protein Refseq : NP_001301
MIM : 603476
UniProt ID : O60519
Chromosome Location : 12p13
Function : protein dimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;

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