Recombinant Human CREBL2 cell lysate

• Cat.No.: CREBL2-398HCL

Specification

• Description: cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: CREBL2 cAMP responsive element binding protein-like 2 [ Homo sapiens ]
• Official Symbol: CREBL2
• Synonyms: CREBL2; cAMP responsive element binding protein-like 2; cAMP-responsive element-binding protein-like 2; MHBs-binding protein 1; MGC117311; MGC138362
• Gene ID: 1389
• mRNA Refseq: NM_001310
• Protein Refseq: NP_001301
• MIM: 603476
• UniProt ID: O60519
• Chromosome Location: 12p13
• Function: protein dimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity