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Recombinant Human CTTN cell lysate

Cat.No. : CTTN-421HCL
  • Specification
  • Gene Information
  • Related Products
Description : This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : CTTN cortactin [ Homo sapiens ]
Official Symbol : CTTN
Synonyms : CTTN; cortactin; EMS1, ems1 sequence (mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); src substrate cortactin; amplaxin; 1110020L01Rik; oncogene EMS1; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate); EMS1; FLJ34459;
Gene ID : 2017
mRNA Refseq : NM_001184740
Protein Refseq : NP_001171669
MIM : 164765
UniProt ID : Q14247
Chromosome Location : 11q13
Pathway : Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; E-cadherin signaling in the nascent adherens junction, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; N-cadherin signaling events, organism-specific biosystem; Pathogenic Escherichia coli infection, organism-specific biosystem; Pathogenic Escherichia coli infection, conserved biosystem;
Function : protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any molecular pathways that interact with CTTN protein in cancer cells? 03/20/2022

Yes, CTTN protein interacts with various signaling pathways involved in cancer progression, including those regulating cell migration and invasion.

How is CTTN protein expression assessed in clinical settings? 01/12/2022

CTTN protein expression can be evaluated using immunohistochemistry on tumor tissue samples obtained from patients.

Are there any non-cancer clinical applications of CTTN protein? 08/01/2020

Yes, CTTN protein has been implicated in neurological disorders such as Alzheimer's disease, and its role in these conditions is also being investigated.

Is CTTN protein involved in other cellular functions besides cancer progression? 03/21/2019

Yes, CTTN protein is involved in various cellular processes such as cell adhesion, migration, and cytoskeletal dynamics.

How is CTTN protein expression regulated in cancer cells? 01/17/2016

CTTN protein expression can be regulated by various factors, including oncogenes, tumor suppressor genes, and signaling pathways involved in cancer development.

Customer Reviews (3)

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Reviews
01/19/2021

    Its high quality, coupled with the manufacturer's exceptional technical support, make it a reliable and effective choice for addressing my scientific inquiries.

    05/17/2017

      This has greatly facilitated my experimental workflow, ensuring a readily available and dependable protein source whenever I need it.

      12/15/2016

        I confidently recommend the CTTN protein to any researcher seeking a superior protein that not only fulfills their experimental needs but is also backed by unparalleled support from the manufacturer.

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